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10.1007/s00281-015-0548-7 http://scihub22266oqcxt.onion/10.1007/s00281-015-0548-7 C4779128!4779128!26678994     free     free     free Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Semin+Immunopathol 2016 ; 38 (ä): 249-60 Nephropedia Template TP {{tp|p=26678994|t=2016. Lessons from other diseases: granulomatous inflammation in leishmaniasis |pdf=|usr=}}{{26678994}} gab.com Text Lessons from other diseases: granulomatous inflammation in leishmaniasis JO: Semin Immunopathol http://www.kidney.de/pget.php?&tw=1&pmid=26678994 #FOAvip The Leishmania granuloma shares some, though not all, properties with that formed following mycobacterial infection. As a simplified, noncaseating granuloma composed of relatively few and largely mononuclear cell populations, it provides a tractable model system to investigate intra-granuloma cellular dynamics, immune regulation, and antimicrobial resistance. Here, the occurrence of granulomatous pathology across the spectrum of leishmaniasis, in humans and animal reservoir hosts, is first described. However, this review focuses on the process of hepatic granuloma formation as studied in rodent models of visceral leishmaniasis, starting from the initial infection of Kupffer cells to the involution of the granuloma after pathogen clearance. It describes how the application of intravital imaging and the use of computational modeling have changed some of our thoughts on granuloma function, and illustrates how host-directed therapies have been used to manipulate granuloma form and function for therapeutic benefit. Where appropriate, lessons that may be equally applicable across the spectrum of granulomatous diseases are highlighted.Electronic supplementary material: The online version of this article (doi:10.1007/s00281-015-0548-7) contains supplementary material, which is available to authorized users. Twit Text FOAVip Lessons from other diseases: granulomatous inflammation in leishmaniasis ????Semin Immunopathol http://www.kidney.de/pget.php?&tw=1&pmid=26678994 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26678994 #FOAvip English Wikipedia <ref>{{Cite pmid|26678994}}</ref> Lessons from other diseases: granulomatous inflammation in leishmaniasis #MMPMID26678994 Kaye PM; Beattie L Semin Immunopathol 2016[]; 38 (ä): 249-60 PMID26678994show ga The Leishmania granuloma shares some, though not all, properties with that formed following mycobacterial infection. As a simplified, noncaseating granuloma composed of relatively few and largely mononuclear cell populations, it provides a tractable model system to investigate intra-granuloma cellular dynamics, immune regulation, and antimicrobial resistance. Here, the occurrence of granulomatous pathology across the spectrum of leishmaniasis, in humans and animal reservoir hosts, is first described. However, this review focuses on the process of hepatic granuloma formation as studied in rodent models of visceral leishmaniasis, starting from the initial infection of Kupffer cells to the involution of the granuloma after pathogen clearance. It describes how the application of intravital imaging and the use of computational modeling have changed some of our thoughts on granuloma function, and illustrates how host-directed therapies have been used to manipulate granuloma form and function for therapeutic benefit. Where appropriate, lessons that may be equally applicable across the spectrum of granulomatous diseases are highlighted.Electronic supplementary material: The online version of this article (doi:10.1007/s00281-015-0548-7) contains supplementary material, which is available to authorized users. äLessons from other diseases: granulomatous inflammation in leishmanias(epmc).pdf DeepDyve Pubget Overpricing