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10.1016/j.clim.2008.03.508 http://scihub22266oqcxt.onion/10.1016/j.clim.2008.03.508 C4778964!4778964!18514033     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Clin+Immunol 2008 ; 128 (2): 259-68 Nephropedia Template TP {{tp|p=18514033|t=2008. Impact of estrogen receptor deficiency on disease expression in the NZM2410 lupus prone mouse |pdf=|usr=}}{{18514033}} gab.com Text Impact of estrogen receptor deficiency on disease expression in the NZM2410 lupus prone mouse JO: Clin Immunol http://www.kidney.de/pget.php?&tw=1&pmid=18514033 #FOAvip Systemic lupus erythematosus (SLE) occurs nine times more often in females than males. The purpose of this study was to determine the impact of estrogen receptor (ER) null genotypes on disease in lupus prone NZM2410 (NZM) and MRL/lpr mice, as a method to define the role of estrogen receptor signaling in lupus. ER? deficient NZM females, but not males, had significantly prolonged survival, reduced proteinuria, renal pathology scores and serum urea nitrogen levels compared to wildtype mice, despite higher serum anti-dsDNA levels. ER? deficient MRL/lpr female, but not male, mice also had significantly less proteinuria and renal pathology scores with no effect on autoantibody levels. Deficiency of ER? had no effect on disease in either strain or sex. Taken together, these data demonstrate a key role for ER?, but not ER?, in the development of lupus like disease, but not autoimmunity, in female NZM and MRL/lpr mice. Twit Text FOAVip Impact of estrogen receptor deficiency on disease expression in the NZM2410 lupus prone mouse ????Clin Immunol http://www.kidney.de/pget.php?&tw=1&pmid=18514033 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=18514033 #FOAvip English Wikipedia <ref>{{Cite pmid|18514033}}</ref> Impact of estrogen receptor deficiency on disease expression in the NZM2410 lupus prone mouse #MMPMID18514033 Svenson JL; EuDaly J; Ruiz P; Korach KS; Gilkeson GS Clin Immunol 2008[Aug]; 128 (2): 259-68 PMID18514033show ga Systemic lupus erythematosus (SLE) occurs nine times more often in females than males. The purpose of this study was to determine the impact of estrogen receptor (ER) null genotypes on disease in lupus prone NZM2410 (NZM) and MRL/lpr mice, as a method to define the role of estrogen receptor signaling in lupus. ER? deficient NZM females, but not males, had significantly prolonged survival, reduced proteinuria, renal pathology scores and serum urea nitrogen levels compared to wildtype mice, despite higher serum anti-dsDNA levels. ER? deficient MRL/lpr female, but not male, mice also had significantly less proteinuria and renal pathology scores with no effect on autoantibody levels. Deficiency of ER? had no effect on disease in either strain or sex. Taken together, these data demonstrate a key role for ER?, but not ER?, in the development of lupus like disease, but not autoimmunity, in female NZM and MRL/lpr mice. äImpact of estrogen receptor deficiency on disease expression in the NZ(epmc).pdf DeepDyve Pubget Overpricing