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10.1038/ni.1663 http://scihub22266oqcxt.onion/10.1038/ni.1663 C4778724!4778724!18849990     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nat+Immunol 2008 ; 9 (11): 1297-306 Nephropedia Template TP {{tp|p=18849990|t=2008. Interactions among the transcription factors Runx1, ROR?t and Foxp3 regulate the differentiation of interleukin 17?producing T cells |pdf=|usr=}}{{18849990}} gab.com Text Interactions among the transcription factors Runx1, ROR t and Foxp3 regulate the differentiation of interleukin 17 producing T cells JO: Nat Immunol http://www.kidney.de/pget.php?&tw=1&pmid=18849990 #FOAvip The molecular mechanisms underlying the differentiation of interleukin 17?producing T helper cells (TH-17 cells) are still poorly understood. Here we show that optimal transcription of the gene encoding interleukin 17 (Il17) required a 2-kilobase promoter and at least one conserved noncoding (enhancer) sequence, CNS-5. Both cis-regulatory elements contained regions that bound the transcription factors ROR?t and Runx1. Runx1 influenced TH-17 differentiation by inducing ROR?t expression and by binding to and acting together with ROR?t during Il17 transcription. However, Runx1 also interacts with the transcription factor Foxp3, and this interaction was necessary for the negative effect of Foxp3 on TH-17 differentiation. Thus, our data support a model in which the differential association of Runx1 with Foxp3 and with ROR?t regulates TH-17 differentiation. Twit Text FOAVip Interactions among the transcription factors Runx1, ROR t and Foxp3 regulate the differentiation of interleukin 17 producing T cells ????Nat Immunol http://www.kidney.de/pget.php?&tw=1&pmid=18849990 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=18849990 #FOAvip English Wikipedia <ref>{{Cite pmid|18849990}}</ref> Interactions among the transcription factors Runx1, ROR?t and Foxp3 regulate the differentiation of interleukin 17?producing T cells #MMPMID18849990 Zhang F; Meng G; Strober W Nat Immunol 2008[Nov]; 9 (11): 1297-306 PMID18849990show ga The molecular mechanisms underlying the differentiation of interleukin 17?producing T helper cells (TH-17 cells) are still poorly understood. Here we show that optimal transcription of the gene encoding interleukin 17 (Il17) required a 2-kilobase promoter and at least one conserved noncoding (enhancer) sequence, CNS-5. Both cis-regulatory elements contained regions that bound the transcription factors ROR?t and Runx1. Runx1 influenced TH-17 differentiation by inducing ROR?t expression and by binding to and acting together with ROR?t during Il17 transcription. However, Runx1 also interacts with the transcription factor Foxp3, and this interaction was necessary for the negative effect of Foxp3 on TH-17 differentiation. Thus, our data support a model in which the differential association of Runx1 with Foxp3 and with ROR?t regulates TH-17 differentiation. äInteractions among the transcription factors Runx1, ROR?t and Foxp3 re(epmc).pdf DeepDyve Pubget Overpricing