Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText. Kick-your-searchterm to multiple Engines kick-your-query now !>

A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.1111/cei.12754 http://scihub22266oqcxt.onion/10.1111/cei.12754 C4778104!4778104!26660535     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Clin+Exp+Immunol 2016 ; 184 (1): 118-25 Nephropedia Template TP {{tp|p=26660535|t=2016. Serum properdin consumption as a biomarker of C5 convertase dysregulation in C3 glomerulopathy |pdf=|usr=}}{{26660535}} gab.com Text Serum properdin consumption as a biomarker of C5 convertase dysregulation in C3 glomerulopathy JO: Clin Exp Immunol http://www.kidney.de/pget.php?&tw=1&pmid=26660535 #FOAvip Properdin (P) stabilizes the alternative pathway (AP) convertases, being the only known positive regulator of the complement system. In addition, P is a pattern recognition molecule able to initiate directly the AP on non?self surfaces. Although P deficiencies have long been known to be associated with Neisseria infections and P is often found deposited at sites of AP activation and tissue injury, the potential role of P in the pathogenesis of complement dysregulation?associated disorders has not been studied extensively. Serum P levels were measured in 49 patients with histological and clinical evidence of C3 glomerulopathy (C3G). Patients were divided into two groups according to the presence or absence of C3 nephritic factor (C3NeF), an autoantibody that stabilizes the AP C3 convertase. The presence of this autoantibody results in a significant reduction in circulating C3 (P < 0·001) and C5 levels (P < 0·05), but does not alter factor B, P and sC5b?9 levels. Interestingly, in our cohort, serum P levels were low in 17 of the 32 C3NeF?negative patients. This group exhibited significant reduction of C3 (P?<?0·001) and C5 (P?<?0·001) and increase of sC5b?9 (P?<?0·001) plasma levels compared to the control group. Also, P consumption was correlated significantly with C3 (r = 0·798, P = 0·0001), C5 (r = 0·806, P?<?0·0001), sC5b?9 (r = ?0·683, P = 0·043) and a higher degree of proteinuria (r = ?0·862, P = 0·013). These results illustrate further the heterogeneity among C3G patients and suggest that P serum levels could be a reliable clinical biomarker to identify patients with underlying surface AP C5 convertase dysregulation. Twit Text FOAVip Serum properdin consumption as a biomarker of C5 convertase dysregulation in C3 glomerulopathy ????Clin Exp Immunol http://www.kidney.de/pget.php?&tw=1&pmid=26660535 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26660535 #FOAvip English Wikipedia <ref>{{Cite pmid|26660535}}</ref> Serum properdin consumption as a biomarker of C5 convertase dysregulation in C3 glomerulopathy #MMPMID26660535 Corvillo F; Bravo García?Morato M; Nozal P; Garrido S; Tortajada A; Rodríguez de Córdoba S; López?Trascasa M Clin Exp Immunol 2016[Apr]; 184 (1): 118-25 PMID26660535show ga Properdin (P) stabilizes the alternative pathway (AP) convertases, being the only known positive regulator of the complement system. In addition, P is a pattern recognition molecule able to initiate directly the AP on non?self surfaces. Although P deficiencies have long been known to be associated with Neisseria infections and P is often found deposited at sites of AP activation and tissue injury, the potential role of P in the pathogenesis of complement dysregulation?associated disorders has not been studied extensively. Serum P levels were measured in 49 patients with histological and clinical evidence of C3 glomerulopathy (C3G). Patients were divided into two groups according to the presence or absence of C3 nephritic factor (C3NeF), an autoantibody that stabilizes the AP C3 convertase. The presence of this autoantibody results in a significant reduction in circulating C3 (P < 0·001) and C5 levels (P < 0·05), but does not alter factor B, P and sC5b?9 levels. Interestingly, in our cohort, serum P levels were low in 17 of the 32 C3NeF?negative patients. This group exhibited significant reduction of C3 (P? äSerum properdin consumption as a biomarker of C5 convertase dysregulat(epmc).pdf DeepDyve Pubget Overpricing