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10.1111/cei.12744 http://scihub22266oqcxt.onion/10.1111/cei.12744 C4778101!4778101!26618514     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Clin+Exp+Immunol 2016 ; 184 (1): 110-7 Nephropedia Template TP {{tp|p=26618514|t=2016. Sialylation of anti?histone immunoglobulin G autoantibodies determines their capabilities to participate in the clearance of late apoptotic cells |pdf=|usr=}}{{26618514}} gab.com Text Sialylation of anti histone immunoglobulin G autoantibodies determines their capabilities to participate in the clearance of late apoptotic cells JO: Clin Exp Immunol http://www.kidney.de/pget.php?&tw=1&pmid=26618514 #FOAvip The Fc portion of immunoglobulin (Ig)G harbours a single glycosylation site. Glycan sialylation is critical for structure and for certain effector functions of IgG. Anti?histone IgG of patients with systemic lupus erythematosus is reportedly responsible for the recruitment of polymorphonuclear cells (PMN) to the clearance of apoptotic cells. Autoantibodies decorating secondary necrotic cells (SNEC) induce proinflammatory responses after activation of blood?borne phagocytes. Analysing the sialylation status of affinity?purified anti?histone IgG in patients with systemic lupus erythematosus (SLE), we demonstrated that the anti?histone IgG was contained preferentially in the non?sialylated fraction. In functional ex?vivo phagocytosis studies, non?sialylated anti?SNEC IgG directed SNEC preferentially into PMN but did not change their cytokine secretion profiles. In contrast, sialylated IgG reduced the phagocytosis by monocytes of SNEC. Moreover, the sialylated anti?SNEC IgG was not simply anti?inflammatory, but switched the cytokine secretion profiles from interleukin (IL)?6/IL?8 to tumour necrosis factor (TNF)??/IL?1?. Here we describe how different sialylation statuses of IgG autoantibodies contribute to the complex inflammatory network that regulates chronic inflammation. Twit Text FOAVip Sialylation of anti histone immunoglobulin G autoantibodies determines their capabilities to participate in the clearance of late apoptotic cells ????Clin Exp Immunol http://www.kidney.de/pget.php?&tw=1&pmid=26618514 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26618514 #FOAvip English Wikipedia <ref>{{Cite pmid|26618514}}</ref> Sialylation of anti?histone immunoglobulin G autoantibodies determines their capabilities to participate in the clearance of late apoptotic cells #MMPMID26618514 Magorivska I; Muņoz LE; Janko C; Dumych T; Rech J; Schett G; Nimmerjahn F; Bilyy R; Herrmann M Clin Exp Immunol 2016[Apr]; 184 (1): 110-7 PMID26618514show ga The Fc portion of immunoglobulin (Ig)G harbours a single glycosylation site. Glycan sialylation is critical for structure and for certain effector functions of IgG. Anti?histone IgG of patients with systemic lupus erythematosus is reportedly responsible for the recruitment of polymorphonuclear cells (PMN) to the clearance of apoptotic cells. Autoantibodies decorating secondary necrotic cells (SNEC) induce proinflammatory responses after activation of blood?borne phagocytes. Analysing the sialylation status of affinity?purified anti?histone IgG in patients with systemic lupus erythematosus (SLE), we demonstrated that the anti?histone IgG was contained preferentially in the non?sialylated fraction. In functional ex?vivo phagocytosis studies, non?sialylated anti?SNEC IgG directed SNEC preferentially into PMN but did not change their cytokine secretion profiles. In contrast, sialylated IgG reduced the phagocytosis by monocytes of SNEC. Moreover, the sialylated anti?SNEC IgG was not simply anti?inflammatory, but switched the cytokine secretion profiles from interleukin (IL)?6/IL?8 to tumour necrosis factor (TNF)??/IL?1?. Here we describe how different sialylation statuses of IgG autoantibodies contribute to the complex inflammatory network that regulates chronic inflammation. äSialylation of anti?histone immunoglobulin G autoantibodies determines(epmc).pdf DeepDyve Pubget Overpricing