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10.1111/cei.12743 http://scihub22266oqcxt.onion/10.1111/cei.12743 C4778092!4778092!26616478     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Clin+Exp+Immunol 2016 ; 184 (1): 11-8 Nephropedia Template TP {{tp|p=26616478|t=2016. Insulin?like growth factor binding protein?2 as a novel biomarker for disease activity and renal pathology changes in lupus nephritis |pdf=|usr=}}{{26616478}} gab.com Text Insulin like growth factor binding protein 2 as a novel biomarker for disease activity and renal pathology changes in lupus nephritis JO: Clin Exp Immunol http://www.kidney.de/pget.php?&tw=1&pmid=26616478 #FOAvip Lupus nephritis (LN) is one of the most serious manifestations of systemic lupus erythematosus. Invasive renal biopsy remains the gold standard for the diagnosis and management of LN. The objective of this study is to validate serum insulin?like growth factor binding protein?2 (IGFBP?2) as a novel biomarker for clinical disease and renal pathology in LN. Eighty?five biopsy?proven lupus nephritis patients, 18 chronic kidney disease (CKD) patients and 20 healthy controls were recruited for enzyme?linked immunosorbent assay (ELISA) testing of serum IGFBP?2 levels. Compared to CKD patients of origins other than lupus or healthy controls, serum IGFBP?2 levels were elevated significantly in LN patients. Serum IGFBP?2 was able to discriminate LN patients from the other two groups of patients [area under the curve (AUC)?=?0·65, 95% confidence interval (CI)?=?0·52?0·78; P = 0·043 for LN versus CKD; 0·97, 95% CI?=?0·93?1·00; P < 0·0001 for LN versus healthy controls]. Serum IGFBP?2 was a potential indicator of both global disease activity and renal disease activity in LN patients, correlated with serum creatinine levels (r?=?0·658, P?<?0·001, n?=?85) and urine protein?to?creatinine levels (r?=?0·397, P?<?0·001, n?=?85). More importantly, in 19 concurrent patient samples, serum IGFBP?2 correlated with the chronicity index of renal pathology (r?=?0·576, P?=?0·01, n?=?19) but not renal pathological classification. In conclusion, serum IGFBP?2 is a promising biomarker for lupus nephritis, reflective of disease activity and chronicity changes in renal pathology. Twit Text FOAVip Insulin like growth factor binding protein 2 as a novel biomarker for disease activity and renal pathology changes in lupus nephritis ????Clin Exp Immunol http://www.kidney.de/pget.php?&tw=1&pmid=26616478 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26616478 #FOAvip English Wikipedia <ref>{{Cite pmid|26616478}}</ref> Insulin?like growth factor binding protein?2 as a novel biomarker for disease activity and renal pathology changes in lupus nephritis #MMPMID26616478 Ding H; Kharboutli M; Saxena R; Wu T Clin Exp Immunol 2016[Apr]; 184 (1): 11-8 PMID26616478show ga Lupus nephritis (LN) is one of the most serious manifestations of systemic lupus erythematosus. Invasive renal biopsy remains the gold standard for the diagnosis and management of LN. The objective of this study is to validate serum insulin?like growth factor binding protein?2 (IGFBP?2) as a novel biomarker for clinical disease and renal pathology in LN. Eighty?five biopsy?proven lupus nephritis patients, 18 chronic kidney disease (CKD) patients and 20 healthy controls were recruited for enzyme?linked immunosorbent assay (ELISA) testing of serum IGFBP?2 levels. Compared to CKD patients of origins other than lupus or healthy controls, serum IGFBP?2 levels were elevated significantly in LN patients. Serum IGFBP?2 was able to discriminate LN patients from the other two groups of patients [area under the curve (AUC)?=?0·65, 95% confidence interval (CI)?=?0·52?0·78; P = 0·043 for LN versus CKD; 0·97, 95% CI?=?0·93?1·00; P < 0·0001 for LN versus healthy controls]. Serum IGFBP?2 was a potential indicator of both global disease activity and renal disease activity in LN patients, correlated with serum creatinine levels (r?=?0·658, P? äInsulin?like growth factor binding protein?2 as a novel biomarker for (epmc).pdf DeepDyve Pubget Overpricing