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10.1038/ncomms10786 http://scihub22266oqcxt.onion/10.1038/ncomms10786 C4778067!4778067 !26931735     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=26931735 &cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\26931735 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Nat+Commun 2016 ; 7 (ä): 10786 Nephropedia Template TP {{tp|p=26931735 |t=2016. mTORC1-mediated inhibition of polycystin-1 expression drives renal cyst formation in tuberous sclerosis complex |pdf=|usr=}}{{26931735 }} gab.com Text mTORC1-mediated inhibition of polycystin-1 expression drives renal cyst formation in tuberous sclerosis complex JO: Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=26931735 #FOAvip Previous studies report a cross-talk between the polycystic kidney disease (PKD) and tuberous sclerosis complex (TSC) genes. mTOR signalling is upregulated in PKD and rapamycin slows cyst expansion, whereas renal inactivation of the Tsc genes causes cysts. Here we identify a new interplay between the PKD and TSC genes, with important implications for the pathophysiology of both diseases. Kidney-specific inactivation of either Pkd1 or Tsc1 using an identical Cre (KspCre) results in aggressive or very mild PKD, respectively. Unexpectedly, we find that mTORC1 negatively regulates the biogenesis of polycystin-1 (PC-1) and trafficking of the PC-1/2 complex to cilia. Genetic interaction studies reveal an important role for PC-1 downregulation by mTORC1 in the cystogenesis of Tsc1 mutants. Our data potentially explain the severe renal manifestations of the TSC/PKD contiguous gene syndrome and open new perspectives for the use of mTOR inhibitors in autosomal dominant PKD caused by hypomorphic or missense PKD1 mutations. Twit Text FOAVip mTORC1-mediated inhibition of polycystin-1 expression drives renal cyst formation in tuberous sclerosis complex ????Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=26931735 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26931735 #FOAvip English Wikipedia <ref>{{Cite pmid|26931735 }}</ref> mTORC1-mediated inhibition of polycystin-1 expression drives renal cyst formation in tuberous sclerosis complex #MMPMID26931735 Pema M ; Drusian L ; Chiaravalli M ; Castelli M ; Yao Q ; Ricciardi S ; Somlo S ; Qian F ; Biffo S ; Boletta A Nat Commun 2016[Mar]; 7 (ä): 10786 PMID26931735 show ga Previous studies report a cross-talk between the polycystic kidney disease (PKD) and tuberous sclerosis complex (TSC) genes. mTOR signalling is upregulated in PKD and rapamycin slows cyst expansion, whereas renal inactivation of the Tsc genes causes cysts. Here we identify a new interplay between the PKD and TSC genes, with important implications for the pathophysiology of both diseases. Kidney-specific inactivation of either Pkd1 or Tsc1 using an identical Cre (KspCre) results in aggressive or very mild PKD, respectively. Unexpectedly, we find that mTORC1 negatively regulates the biogenesis of polycystin-1 (PC-1) and trafficking of the PC-1/2 complex to cilia. Genetic interaction studies reveal an important role for PC-1 downregulation by mTORC1 in the cystogenesis of Tsc1 mutants. Our data potentially explain the severe renal manifestations of the TSC/PKD contiguous gene syndrome and open new perspectives for the use of mTOR inhibitors in autosomal dominant PKD caused by hypomorphic or missense PKD1 mutations. |Animals [MESH] |Cilia [MESH] |Cysts/*pathology [MESH] |Down-Regulation [MESH] |Gene Expression Regulation/drug effects/*physiology [MESH] |Gene Silencing [MESH] |Mechanistic Target of Rapamycin Complex 1 [MESH] |Mice [MESH] |Multiprotein Complexes/genetics/*metabolism [MESH] |Polycystic Kidney Diseases/genetics/metabolism [MESH] |Sirolimus/pharmacology [MESH] |TOR Serine-Threonine Kinases/genetics/*metabolism [MESH] |TRPP Cation Channels/genetics/*metabolism [MESH] |Tuberous Sclerosis/genetics/*metabolism/pathology [MESH]mTORC1-mediated inhibition of polycystin-1 expression drives renal cys(epmc).pdf DeepDyve Pubget Overpricing