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10.1038/ncomms10716 http://scihub22266oqcxt.onion/10.1038/ncomms10716 C4778049!4778049 !26931494     free     free     free Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\26931494 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Nat+Commun 2016 ; 7 (ä): 10716 Nephropedia Template TP {{tp|p=26931494 |t=2016. A Helitron transposon reconstructed from bats reveals a novel mechanism of genome shuffling in eukaryotes |pdf=|usr=}}{{26931494 }} gab.com Text A Helitron transposon reconstructed from bats reveals a novel mechanism of genome shuffling in eukaryotes JO: Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=26931494 #FOAvip Helitron transposons capture and mobilize gene fragments in eukaryotes, but experimental evidence for their transposition is lacking in the absence of an isolated active element. Here we reconstruct Helraiser, an ancient element from the bat genome, and use this transposon as an experimental tool to unravel the mechanism of Helitron transposition. A hairpin close to the 3'-end of the transposon functions as a transposition terminator. However, the 3'-end can be bypassed by the transposase, resulting in transduction of flanking sequences to new genomic locations. Helraiser transposition generates covalently closed circular intermediates, suggestive of a replicative transposition mechanism, which provides a powerful means to disseminate captured transcriptional regulatory signals across the genome. Indeed, we document the generation of novel transcripts by Helitron promoter capture both experimentally and by transcriptome analysis in bats. Our results provide mechanistic insight into Helitron transposition, and its impact on diversification of gene function by genome shuffling. Twit Text FOAVip A Helitron transposon reconstructed from bats reveals a novel mechanism of genome shuffling in eukaryotes ????Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=26931494 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26931494 #FOAvip English Wikipedia <ref>{{Cite pmid|26931494 }}</ref> A Helitron transposon reconstructed from bats reveals a novel mechanism of genome shuffling in eukaryotes #MMPMID26931494 Grabundzija I ; Messing SA ; Thomas J ; Cosby RL ; Bilic I ; Miskey C ; Gogol-Döring A ; Kapitonov V ; Diem T ; Dalda A ; Jurka J ; Pritham EJ ; Dyda F ; Izsvák Z ; Ivics Z Nat Commun 2016[Mar]; 7 (ä): 10716 PMID26931494 show ga Helitron transposons capture and mobilize gene fragments in eukaryotes, but experimental evidence for their transposition is lacking in the absence of an isolated active element. Here we reconstruct Helraiser, an ancient element from the bat genome, and use this transposon as an experimental tool to unravel the mechanism of Helitron transposition. A hairpin close to the 3'-end of the transposon functions as a transposition terminator. However, the 3'-end can be bypassed by the transposase, resulting in transduction of flanking sequences to new genomic locations. Helraiser transposition generates covalently closed circular intermediates, suggestive of a replicative transposition mechanism, which provides a powerful means to disseminate captured transcriptional regulatory signals across the genome. Indeed, we document the generation of novel transcripts by Helitron promoter capture both experimentally and by transcriptome analysis in bats. Our results provide mechanistic insight into Helitron transposition, and its impact on diversification of gene function by genome shuffling. |*Genetic Variation [MESH] |*Genome [MESH] |Animals [MESH] |Chiroptera/*genetics [MESH] |DNA Transposable Elements/*genetics [MESH] |HeLa Cells [MESH]A Helitron transposon reconstructed from bats reveals a novel mechanis(epmc).pdf DeepDyve Pubget Overpricing