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.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 World+J+Gastroenterol
2016 ; 22
(9
): 2678-700
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Key players in pancreatic cancer-stroma interaction: Cancer-associated
fibroblasts, endothelial and inflammatory cells
#MMPMID26973408
Nielsen MF
; Mortensen MB
; Detlefsen S
World J Gastroenterol
2016[Mar]; 22
(9
): 2678-700
PMID26973408
show ga
Pancreatic cancer (PC) is the most aggressive type of common cancers, and in
2014, nearly 40000 patients died from the disease in the United States.
Pancreatic ductal adenocarcinoma, which accounts for the majority of PC cases, is
characterized by an intense stromal desmoplastic reaction surrounding the cancer
cells. Cancer-associated fibroblasts (CAFs) are the main effector cells in the
desmoplastic reaction, and pancreatic stellate cells are the most important
source of CAFs. However, other important components of the PC stroma are
inflammatory cells and endothelial cells. The aim of this review is to describe
the complex interplay between PC cells and the cellular and non-cellular
components of the tumour stroma. Published data have indicated that the
desmoplastic stroma protects PC cells against chemotherapy and radiation therapy
and that it might promote the proliferation and migration of PC cells. However,
in animal studies, experimental depletion of the desmoplastic stroma and CAFs has
led to more aggressive cancers. Hence, the precise role of the tumour stroma in
PC remains to be elucidated. However, it is likely that a context-dependent
therapeutic modification, rather than pure depletion, of the PC stroma holds
potential for the development of new treatment strategies for PC patients.
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