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10.1074/jbc.M115.681122 http://scihub22266oqcxt.onion/10.1074/jbc.M115.681122 C4777864!4777864 !26769966     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=26769966 &cmd=llinks): Failed to open stream: HTTP request failed! 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Transmembrane Protein 184A Is a Receptor Required for Vascular Smooth Muscle Cell Responses to Heparin |pdf=|usr=}}{{26769966 }} gab.com Text Transmembrane Protein 184A Is a Receptor Required for Vascular Smooth Muscle Cell Responses to Heparin JO: J Biol Chem http://www.kidney.de/pget.php?&tw=1&pmid=26769966 #FOAvip Vascular cell responses to exogenous heparin have been documented to include decreased vascular smooth muscle cell proliferation following decreased ERK pathway signaling. However, the molecular mechanism(s) by which heparin interacts with cells to induce those responses has remained unclear. Previously characterized monoclonal antibodies that block heparin binding to vascular cells have been found to mimic heparin effects. In this study, those antibodies were employed to isolate a heparin binding protein. MALDI mass spectrometry data provide evidence that the protein isolated is transmembrane protein 184A (TMEM184A). Commercial antibodies against three separate regions of the TMEM184A human protein were used to identify the TMEM184A protein in vascular smooth muscle cells and endothelial cells. A GFP-TMEM184A construct was employed to determine colocalization with heparin after endocytosis. Knockdown of TMEM184A eliminated the physiological responses to heparin, including effects on ERK pathway activity and BrdU incorporation. Isolated GFP-TMEM184A binds heparin, and overexpression results in additional heparin uptake. Together, these data support the identification of TMEM184A as a heparin receptor in vascular cells. Twit Text FOAVip Transmembrane Protein 184A Is a Receptor Required for Vascular Smooth Muscle Cell Responses to Heparin ????J Biol Chem http://www.kidney.de/pget.php?&tw=1&pmid=26769966 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26769966 #FOAvip English Wikipedia <ref>{{Cite pmid|26769966 }}</ref> Transmembrane Protein 184A Is a Receptor Required for Vascular Smooth Muscle Cell Responses to Heparin #MMPMID26769966 Pugh RJ ; Slee JB ; Farwell SL ; Li Y ; Barthol T ; Patton WA ; Lowe-Krentz LJ J Biol Chem 2016[Mar]; 291 (10 ): 5326-41 PMID26769966 show ga Vascular cell responses to exogenous heparin have been documented to include decreased vascular smooth muscle cell proliferation following decreased ERK pathway signaling. However, the molecular mechanism(s) by which heparin interacts with cells to induce those responses has remained unclear. Previously characterized monoclonal antibodies that block heparin binding to vascular cells have been found to mimic heparin effects. In this study, those antibodies were employed to isolate a heparin binding protein. MALDI mass spectrometry data provide evidence that the protein isolated is transmembrane protein 184A (TMEM184A). Commercial antibodies against three separate regions of the TMEM184A human protein were used to identify the TMEM184A protein in vascular smooth muscle cells and endothelial cells. A GFP-TMEM184A construct was employed to determine colocalization with heparin after endocytosis. Knockdown of TMEM184A eliminated the physiological responses to heparin, including effects on ERK pathway activity and BrdU incorporation. Isolated GFP-TMEM184A binds heparin, and overexpression results in additional heparin uptake. Together, these data support the identification of TMEM184A as a heparin receptor in vascular cells. |Amino Acid Sequence [MESH] |Animals [MESH] |Binding Sites [MESH] |Cell Line [MESH] |Heparin/*pharmacology [MESH] |Humans [MESH] |Molecular Sequence Data [MESH] |Muscle, Smooth, Vascular/drug effects/*metabolism [MESH] |Protein Binding [MESH] |Protein Transport [MESH] |Rats [MESH] |Receptors, Cell Surface/genetics/*metabolism [MESH]Transmembrane Protein 184A Is a Receptor Required for Vascular Smooth (epmc).pdf DeepDyve Pubget Overpricing