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.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Front+Aging+Neurosci
2016 ; 8
(ä): 45
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Astrocytes As the Main Players in Primary Degenerative Disorders of the Human
Central Nervous System
#MMPMID26973519
Capani F
; Quarracino C
; Caccuri R
; Sica RE
Front Aging Neurosci
2016[]; 8
(ä): 45
PMID26973519
show ga
Along the last years it has been demonstrated that non-neural cells play a major
role in the pathogenesis of the primary degenerative disorders (PDDs) of the
human central nervous system. Among them, astrocytes coordinate and participate
in many different and complex metabolic processes, in close interaction with
neurons. Moreover, increasing experimental evidence hints an early astrocytic
dysfunction in these diseases. In this mini review we summarize the astrocytic
behavior in PDDs, with special consideration to the experimental observations
where astrocytic pathology precedes the development of neuronal dysfunction. We
also suggest a different approach that could be consider in human investigations
in Alzheimer's and Parkinson's disease. We believe that the study of PDDs with
human brain samples may hold the key of a paradigmatic physiopathological process
in which astrocytes might be the main players.