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10.1016/j.neuron.2016.01.023 http://scihub22266oqcxt.onion/10.1016/j.neuron.2016.01.023 C4777634!4777634!26898775     free     free     free Deprecated: Implicit conversion from float 225.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 225.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Neuron 2016 ; 89 (5): 1059-73 Nephropedia Template TP {{tp|p=26898775|t=2016. Cannabinoid control of learning and memory through HCN channels |pdf=|usr=}}{{26898775}} gab.com Text Cannabinoid control of learning and memory through HCN channels JO: Neuron http://www.kidney.de/pget.php?&tw=1&pmid=26898775 #FOAvip The mechanisms underlying the effects of cannabinoids on cognitive processes are not understood. Here we show that cannabinoid type-1 receptors (CB1Rs) control hippocampal synaptic plasticity and spatial memory through the hyperpolarization-activated cyclic nucleotide-gated (HCN) channels that underlie the h-current (Ih), a key regulator of dendritic excitability. The CB1R-HCN pathway, involving c-Jun-N-terminal kinases (JNKs), nitric oxide synthase and intracellular cGMP, exerts a tonic enhancement of Ih selectively in pyramidal cells located in the superficial portion of the CA1 pyramidal cell layer, whereas it is absent from deep-layer cells. Activation of CB1R-HCN pathway impairs dendritic integration of excitatory inputs, long-term potentiation (LTP) and spatial memory formation. Strikingly, pharmacological inhibition of Ih or genetic deletion of HCN1 abolishes CB1R-induced deficits in LTP and memory. These results demonstrate that the CB1R-Ih pathway in the hippocampus is obligatory for the action of cannabinoids on LTP and spatial memory formation. Twit Text FOAVip Cannabinoid control of learning and memory through HCN channels ????Neuron http://www.kidney.de/pget.php?&tw=1&pmid=26898775 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26898775 #FOAvip English Wikipedia <ref>{{Cite pmid|26898775}}</ref> Cannabinoid control of learning and memory through HCN channels #MMPMID26898775 Maroso M; Szabo GG; Kim HK; Alexander A; Bui AD; Lee SH; Lutz B; Soltesz I Neuron 2016[Mar]; 89 (5): 1059-73 PMID26898775show ga The mechanisms underlying the effects of cannabinoids on cognitive processes are not understood. Here we show that cannabinoid type-1 receptors (CB1Rs) control hippocampal synaptic plasticity and spatial memory through the hyperpolarization-activated cyclic nucleotide-gated (HCN) channels that underlie the h-current (Ih), a key regulator of dendritic excitability. The CB1R-HCN pathway, involving c-Jun-N-terminal kinases (JNKs), nitric oxide synthase and intracellular cGMP, exerts a tonic enhancement of Ih selectively in pyramidal cells located in the superficial portion of the CA1 pyramidal cell layer, whereas it is absent from deep-layer cells. Activation of CB1R-HCN pathway impairs dendritic integration of excitatory inputs, long-term potentiation (LTP) and spatial memory formation. Strikingly, pharmacological inhibition of Ih or genetic deletion of HCN1 abolishes CB1R-induced deficits in LTP and memory. These results demonstrate that the CB1R-Ih pathway in the hippocampus is obligatory for the action of cannabinoids on LTP and spatial memory formation. äCannabinoid control of learning and memory through HCN channels (epmc).pdf DeepDyve Pubget Overpricing