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2016 ; 10
(3
): e0004349
Nephropedia Template TP
gab.com Text
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English Wikipedia
A Historical Overview of the Classification, Evolution, and Dispersion of
Leishmania Parasites and Sandflies
#MMPMID26937644
Akhoundi M
; Kuhls K
; Cannet A
; Votępka J
; Marty P
; Delaunay P
; Sereno D
PLoS Negl Trop Dis
2016[Mar]; 10
(3
): e0004349
PMID26937644
show ga
BACKGROUND: The aim of this study is to describe the major evolutionary
historical events among Leishmania, sandflies, and the associated animal
reservoirs in detail, in accordance with the geographical evolution of the Earth,
which has not been previously discussed on a large scale. METHODOLOGY AND
PRINCIPAL FINDINGS: Leishmania and sandfly classification has always been a
controversial matter, and the increasing number of species currently described
further complicates this issue. Despite several hypotheses on the origin,
evolution, and distribution of Leishmania and sandflies in the Old and New World,
no consistent agreement exists regarding dissemination of the actors that play
roles in leishmaniasis. For this purpose, we present here three centuries of
research on sandflies and Leishmania descriptions, as well as a complete
description of Leishmania and sandfly fossils and the emergence date of each
Leishmania and sandfly group during different geographical periods, from 550
million years ago until now. We discuss critically the different approaches that
were used for Leishmana and sandfly classification and their synonymies,
proposing an updated classification for each species of Leishmania and sandfly.
We update information on the current distribution and dispersion of different
species of Leishmania (53), sandflies (more than 800 at genus or subgenus level),
and animal reservoirs in each of the following geographical ecozones: Palearctic,
Nearctic, Neotropic, Afrotropical, Oriental, Malagasy, and Australian. We propose
an updated list of the potential and proven sandfly vectors for each Leishmania
species in the Old and New World. Finally, we address a classical question about
digenetic Leishmania evolution: which was the first host, a vertebrate or an
invertebrate? CONCLUSIONS AND SIGNIFICANCE: We propose an updated view of events
that have played important roles in the geographical dispersion of sandflies, in
relation to both the Leishmania species they transmit and the animal reservoirs
of the parasites.