The utility of protein and mRNA correlation #MMPMID25467744
Payne SH
Trends Biochem Sci 2015[Jan]; 40 (1): 1-3 PMID25467744show ga
Transcriptomic, proteomic, and metabolomic measurements are revolutionizing the way we model and predict cellular behavior, and multi-omic comparisons are being published with increased regularity. Some have expected a trivial and predictable correlation between mRNA and protein; however, the manifest complexity of biological regulation suggests a more nuanced relationship. Indeed, observing this lack of strict correlation provides clues for new research topics, and has the potential for transformative biological insight.