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10.1038/ni.3211 http://scihub22266oqcxt.onion/10.1038/ni.3211 C4776746!4776746!26168081     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nat+Immunol 2015 ; 16 (9): 970-9 Nephropedia Template TP {{tp|p=26168081|t=2015. TH17 cells promote microbial killing and innate immune sensing of DNA via interleukin 26 |pdf=|usr=}}{{26168081}} gab.com Text TH17 cells promote microbial killing and innate immune sensing of DNA via interleukin 26 JO: Nat Immunol http://www.kidney.de/pget.php?&tw=1&pmid=26168081 #FOAvip Interleukin 17?producing helper T cells (TH17 cells) have a major role in protection against infections and in mediating autoimmune diseases, yet the mechanisms involved are incompletely understood. We found that interleukin 26 (IL-26), a human TH17 cell?derived cytokine, is a cationic amphipathic protein that kills extracellular bacteria via membrane-pore formation. Furthermore, TH17 cell?derived IL-26 formed complexes with bacterial DNA and self-DNA released by dying bacteria and host cells. The resulting IL-26?DNA complexes triggered the production of type I interferon by plasmacytoid dendritic cells via activation of Toll-like receptor 9, but independently of the IL-26 receptor. These findings provide insights into the potent antimicrobial and proinflammatory function of TH17 cells by showing that IL-26 is a natural human antimicrobial that promotes immune sensing of bacterial and host cell death. Twit Text FOAVip TH17 cells promote microbial killing and innate immune sensing of DNA via interleukin 26 ????Nat Immunol http://www.kidney.de/pget.php?&tw=1&pmid=26168081 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26168081 #FOAvip English Wikipedia <ref>{{Cite pmid|26168081}}</ref> TH17 cells promote microbial killing and innate immune sensing of DNA via interleukin 26 #MMPMID26168081 Meller S; Domizio JD; Voo KS; Friedrich HC; Chamilos G; Ganguly D; Conrad C; Gregorio J; Roy DL; Roger T; Ladbury JE; Homey B; Watowich S; Modlin RL; Kontoyiannis DP; Liu YJ; Arold ST; Gilliet M Nat Immunol 2015[Sep]; 16 (9): 970-9 PMID26168081show ga Interleukin 17?producing helper T cells (TH17 cells) have a major role in protection against infections and in mediating autoimmune diseases, yet the mechanisms involved are incompletely understood. We found that interleukin 26 (IL-26), a human TH17 cell?derived cytokine, is a cationic amphipathic protein that kills extracellular bacteria via membrane-pore formation. Furthermore, TH17 cell?derived IL-26 formed complexes with bacterial DNA and self-DNA released by dying bacteria and host cells. The resulting IL-26?DNA complexes triggered the production of type I interferon by plasmacytoid dendritic cells via activation of Toll-like receptor 9, but independently of the IL-26 receptor. These findings provide insights into the potent antimicrobial and proinflammatory function of TH17 cells by showing that IL-26 is a natural human antimicrobial that promotes immune sensing of bacterial and host cell death. äTH17 cells promote microbial killing and innate immune sensing of DNA (epmc).pdf DeepDyve Pubget Overpricing