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10.1093/molbev/msv344 http://scihub22266oqcxt.onion/10.1093/molbev/msv344 C4776709!4776709!26715627     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Mol+Biol+Evol 2016 ; 33 (4): 1008-18 Nephropedia Template TP {{tp|p=26715627|t=2016. Accelerated Evolution of Enhancer Hotspots in the Mammal Ancestor |pdf=|usr=}}{{26715627}} gab.com Text Accelerated Evolution of Enhancer Hotspots in the Mammal Ancestor JO: Mol Biol Evol http://www.kidney.de/pget.php?&tw=1&pmid=26715627 #FOAvip Mammals have evolved remarkably different sensory, reproductive, metabolic, and skeletal systems. To explore the genetic basis for these differences, we developed a comparative genomics approach to scan whole-genome multiple sequence alignments to identify regions that evolved rapidly in an ancestral lineage but are conserved within extant species. This pattern suggests that ancestral changes in function were maintained in descendants. After applying this test to therian mammals, we identified 4,797 accelerated regions, many of which are noncoding and located near developmental transcription factors. We then used mouse transgenic reporter assays to test if noncoding accelerated regions are enhancers and to determine how therian-specific substitutions affect their activity in vivo. We discovered enhancers with expression specific to the therian version in brain regions involved in the hormonal control of milk ejection, uterine contractions, blood pressure, temperature, and visual processing. This work underscores the idea that changes in developmental gene expression are important for mammalian evolution, and it pinpoints candidate genes for unique aspects of mammalian biology. Twit Text FOAVip Accelerated Evolution of Enhancer Hotspots in the Mammal Ancestor ????Mol Biol Evol http://www.kidney.de/pget.php?&tw=1&pmid=26715627 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26715627 #FOAvip English Wikipedia <ref>{{Cite pmid|26715627}}</ref> Accelerated Evolution of Enhancer Hotspots in the Mammal Ancestor #MMPMID26715627 Holloway AK; Bruneau BG; Sukonnik T; Rubenstein JL; Pollard KS Mol Biol Evol 2016[Apr]; 33 (4): 1008-18 PMID26715627show ga Mammals have evolved remarkably different sensory, reproductive, metabolic, and skeletal systems. To explore the genetic basis for these differences, we developed a comparative genomics approach to scan whole-genome multiple sequence alignments to identify regions that evolved rapidly in an ancestral lineage but are conserved within extant species. This pattern suggests that ancestral changes in function were maintained in descendants. After applying this test to therian mammals, we identified 4,797 accelerated regions, many of which are noncoding and located near developmental transcription factors. We then used mouse transgenic reporter assays to test if noncoding accelerated regions are enhancers and to determine how therian-specific substitutions affect their activity in vivo. We discovered enhancers with expression specific to the therian version in brain regions involved in the hormonal control of milk ejection, uterine contractions, blood pressure, temperature, and visual processing. This work underscores the idea that changes in developmental gene expression are important for mammalian evolution, and it pinpoints candidate genes for unique aspects of mammalian biology. äAccelerated Evolution of Enhancer Hotspots in the Mammal Ancestor (epmc).pdf DeepDyve Pubget Overpricing