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2014 ; 64
(12
): 1084-1091
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Mechanobiology of Ciliogenesis
#MMPMID26954101
Ishikawa H
; Marshall WF
Bioscience
2014[Dec]; 64
(12
): 1084-1091
PMID26954101
show ga
Cilia are force-generating and -sensing organelles that serve as mechanical
interfaces between the cell and the extracellular environment. Cilia are present
in tissues that adaptively respond to mechanical loading and fluid flow, and
defects in ciliary function can lead to diseases affecting these tissues. As
might be expected for a mechanical interface, the formation of cilia is, itself,
regulated by mechanical forces, and these links between mechanics and ciliary
formation are providing new entry points for dissecting the regulatory pathways
of ciliogenesis.