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10.1093/biosci/biu180 http://scihub22266oqcxt.onion/10.1093/biosci/biu180 C4776691!4776691!26955066     free     free     free       Bioscience 2014 ; 64 (12): 1073-83 Nephropedia Template TP {{tp|p=26955066|t=2014. A Structural Basis for How Motile Cilia Beat |pdf=|usr=}}{{26955066}} gab.com Text A Structural Basis for How Motile Cilia Beat JO: Bioscience http://www.kidney.de/pget.php?&tw=1&pmid=26955066 #FOAvip The motile cilium is a mechanical wonder, a cellular nanomachine that produces a high-speed beat based on a cycle of bends that move along an axoneme made of 9+2 microtubules. The molecular motors, dyneins, power the ciliary beat. The dyneins are compacted into inner and outer dynein arms, whose activity is highly regulated to produce microtubule sliding and axonemal bending. The switch point hypothesis was developed long ago to account for how sliding in the presence of axonemal radial spoke?central pair interactions causes the ciliary beat. Since then, a new genetic, biochemical, and structural complexity has been discovered, in part, with Chlamydomonas mutants, with high-speed, high-resolution analysis of movement and with cryoelectron tomography. We stand poised on the brink of new discoveries relating to the molecular control of motility that extend and refine our understanding of the basic events underlying the switching of arm activity and of bend formation and propagation. Twit Text FOAVip A Structural Basis for How Motile Cilia Beat ????Bioscience http://www.kidney.de/pget.php?&tw=1&pmid=26955066 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26955066 #FOAvip English Wikipedia <ref>{{Cite pmid|26955066}}</ref> A Structural Basis for How Motile Cilia Beat #MMPMID26955066 Satir P; Heuser T; Sale WS Bioscience 2014[Dec]; 64 (12): 1073-83 PMID26955066show ga The motile cilium is a mechanical wonder, a cellular nanomachine that produces a high-speed beat based on a cycle of bends that move along an axoneme made of 9+2 microtubules. The molecular motors, dyneins, power the ciliary beat. The dyneins are compacted into inner and outer dynein arms, whose activity is highly regulated to produce microtubule sliding and axonemal bending. The switch point hypothesis was developed long ago to account for how sliding in the presence of axonemal radial spoke?central pair interactions causes the ciliary beat. Since then, a new genetic, biochemical, and structural complexity has been discovered, in part, with Chlamydomonas mutants, with high-speed, high-resolution analysis of movement and with cryoelectron tomography. We stand poised on the brink of new discoveries relating to the molecular control of motility that extend and refine our understanding of the basic events underlying the switching of arm activity and of bend formation and propagation. äA Structural Basis for How Motile Cilia Beat (epmc).pdf DeepDyve Pubget Overpricing