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Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Bioscience 2014 ; 64 (12): 1115-25 Nephropedia Template TP
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Linking the Primary Cilium to Cell Migration in Tissue Repair and Brain Development #MMPMID26955067
Veland IR; Lindbæk L; Christensen ST
Bioscience 2014[Dec]; 64 (12): 1115-25 PMID26955067show ga
Primary cilia are unique sensory organelles that coordinate cellular signaling networks in vertebrates. Inevitably, defects in the formation or function of primary cilia lead to imbalanced regulation of cellular processes that causes multisystemic disorders and diseases, commonly known as ciliopathies. Mounting evidence has demonstrated that primary cilia coordinate multiple activities that are required for cell migration, which, when they are aberrantly regulated, lead to defects in organogenesis and tissue repair, as well as metastasis of tumors. Here, we present an overview on how primary cilia may contribute to the regulation of the cellular signaling pathways that control cyclic processes in directional cell migration.