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10.1177/0271678X15616782

http://scihub22266oqcxt.onion/10.1177/0271678X15616782
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C4776310!4776310!26661235
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suck abstract from ncbi


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pmid26661235      J+Cereb+Blood+Flow+Metab 2016 ; 36 (3): 487-91
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  • Feasibility of progesterone treatment for ischaemic stroke #MMPMID26661235
  • Gibson CL; Bath PM
  • J Cereb Blood Flow Metab 2016[Mar]; 36 (3): 487-91 PMID26661235show ga
  • Two multi-centre phase III clinical trials examining the protective potential of progesterone following traumatic brain injury have recently failed to demonstrate any improvement in outcome. Thus, it is timely to consider how this impacts on the translational potential of progesterone treatment for ischaemic stroke. A wealth of experimental evidence supports the neuroprotective properties of progesterone, and associated metabolites, following various types of central nervous system injury. In particular, for ischaemic stroke, studies have also begun to reveal possible mechanisms of such neuroprotection. However, the results in traumatic brain injury now question whether further clinical development of progesterone for ischaemic stroke is relevant.
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