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10.3390/v8020032

http://scihub22266oqcxt.onion/10.3390/v8020032
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C4776187!4776187!26828514
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suck abstract from ncbi

pmid26828514      Viruses 2016 ; 8 (2): ä
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  • The Autophagic Machinery in Enterovirus Infection #MMPMID26828514
  • Lai JKF; Sam IC; Chan YF
  • Viruses 2016[Feb]; 8 (2): ä PMID26828514show ga
  • The Enterovirus genus of the Picornaviridae family comprises many important human pathogens, including polioviruses, rhinovirus, enterovirus A71, and enterovirus D68. They cause a wide variety of diseases, ranging from mild to severe life-threatening diseases. Currently, no effective vaccine is available against enteroviruses except for poliovirus. Enteroviruses subvert the autophagic machinery to benefit their assembly, maturation, and exit from host. Some enteroviruses spread between cells via a process described as autophagosome-mediated exit without lysis (AWOL). The early and late phases of autophagy are regulated through various lipids and their metabolizing enzymes. Some of these lipids and enzymes are specifically regulated by enteroviruses. In the present review, we summarize the current understanding of the regulation of autophagic machinery by enteroviruses, and provide updates on recent developments in this field.
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