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10.1038/srep22450 http://scihub22266oqcxt.onion/10.1038/srep22450 C4776135!4776135!26936329     free     free     free Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Sci+Rep 2016 ; 6 (ä): ä Nephropedia Template TP {{tp|p=26936329|t=2016. Small Molecule Inhibition of Ligand-Stimulated RAGE-DIAPH1 Signal Transduction |pdf=|usr=}}{{26936329}} gab.com Text Small Molecule Inhibition of Ligand-Stimulated RAGE-DIAPH1 Signal Transduction JO: Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=26936329 #FOAvip The receptor for advanced glycation endproducts (RAGE) binds diverse ligands linked to chronic inflammation and disease. NMR spectroscopy and x-ray crystallization studies of the extracellular domains of RAGE indicate that RAGE ligands bind by distinct charge- and hydrophobicity-dependent mechanisms. The cytoplasmic tail (ct) of RAGE is essential for RAGE ligand-mediated signal transduction and consequent modulation of gene expression and cellular properties. RAGE signaling requires interaction of ctRAGE with the intracellular effector, mammalian diaphanous 1 or DIAPH1. We screened a library of 58,000 small molecules and identified 13 small molecule competitive inhibitors of ctRAGE interaction with DIAPH1. These compounds, which exhibit in vitro and in vivo inhibition of RAGE-dependent molecular processes, present attractive molecular scaffolds for the development of therapeutics against RAGE-mediated diseases, such as those linked to diabetic complications, Alzheimer?s disease, and chronic inflammation, and provide support for the feasibility of inhibition of protein-protein interaction (PPI). Twit Text FOAVip Small Molecule Inhibition of Ligand-Stimulated RAGE-DIAPH1 Signal Transduction ????Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=26936329 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26936329 #FOAvip English Wikipedia <ref>{{Cite pmid|26936329}}</ref> Small Molecule Inhibition of Ligand-Stimulated RAGE-DIAPH1 Signal Transduction #MMPMID26936329 Manigrasso MB; Pan J; Rai V; Zhang J; Reverdatto S; Quadri N; DeVita RJ; Ramasamy R; Shekhtman A; Schmidt AM Sci Rep 2016[]; 6 (ä): ä PMID26936329show ga The receptor for advanced glycation endproducts (RAGE) binds diverse ligands linked to chronic inflammation and disease. NMR spectroscopy and x-ray crystallization studies of the extracellular domains of RAGE indicate that RAGE ligands bind by distinct charge- and hydrophobicity-dependent mechanisms. The cytoplasmic tail (ct) of RAGE is essential for RAGE ligand-mediated signal transduction and consequent modulation of gene expression and cellular properties. RAGE signaling requires interaction of ctRAGE with the intracellular effector, mammalian diaphanous 1 or DIAPH1. We screened a library of 58,000 small molecules and identified 13 small molecule competitive inhibitors of ctRAGE interaction with DIAPH1. These compounds, which exhibit in vitro and in vivo inhibition of RAGE-dependent molecular processes, present attractive molecular scaffolds for the development of therapeutics against RAGE-mediated diseases, such as those linked to diabetic complications, Alzheimer?s disease, and chronic inflammation, and provide support for the feasibility of inhibition of protein-protein interaction (PPI). äSmall Molecule Inhibition of Ligand-Stimulated RAGE-DIAPH1 Signal Tran(epmc).pdf DeepDyve Pubget Overpricing