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10.1016/j.ebiom.2016.01.019 http://scihub22266oqcxt.onion/10.1016/j.ebiom.2016.01.019 C4776068!4776068!26981571     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       EBioMedicine 2016 ; 4 (ä): 50-61 Nephropedia Template TP {{tp|p=26981571|t=2016. Modulation of mTOR Signalling Triggers the Formation of Stem Cell-like Memory T Cells |pdf=|usr=}}{{26981571}} gab.com Text Modulation of mTOR Signalling Triggers the Formation of Stem Cell-like Memory T Cells JO: EBioMedicine http://www.kidney.de/pget.php?&tw=1&pmid=26981571 #FOAvip Robust, long-lasting immune responses are elicited by memory T cells that possess properties of stem cells, enabling them to persist long-term and to permanently replenish the effector pools. Thus, stem cell-like memory T (TSCM) cells are of key therapeutic value and efforts are underway to characterize TSCM cells and to identify means for their targeted induction.Here, we show that inhibition of mechanistic/mammalian Target of Rapamycin (mTOR) complex 1 (mTORC1) by rapamycin or the Wnt-?-catenin signalling activator TWS119 in activated human naive T cells leads to the induction of TSCM cells. We show that these compounds switch T cell metabolism to fatty acid oxidation as favoured metabolic programme for TSCM cell generation. Of note, pharmacologically induced TSCM cells possess superior functional features as a long-term repopulation capacity after adoptive transfer. Furthermore, we provide insights into the transcriptome of TSCM cells.Our data identify a mechanism of pharmacological mTORC1 inhibitors, allowing us to confer stemness to human naive T cells which may be significantly relevant for the design of innovative T cell-based cancer immunotherapies. Twit Text FOAVip Modulation of mTOR Signalling Triggers the Formation of Stem Cell-like Memory T Cells ????EBioMedicine http://www.kidney.de/pget.php?&tw=1&pmid=26981571 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26981571 #FOAvip English Wikipedia <ref>{{Cite pmid|26981571}}</ref> Modulation of mTOR Signalling Triggers the Formation of Stem Cell-like Memory T Cells #MMPMID26981571 Scholz G; Jandus C; Zhang L; Grandclément C; Lopez-Mejia IC; Soneson C; Delorenzi M; Fajas L; Held W; Dormond O; Romero P EBioMedicine 2016[Feb]; 4 (ä): 50-61 PMID26981571show ga Robust, long-lasting immune responses are elicited by memory T cells that possess properties of stem cells, enabling them to persist long-term and to permanently replenish the effector pools. Thus, stem cell-like memory T (TSCM) cells are of key therapeutic value and efforts are underway to characterize TSCM cells and to identify means for their targeted induction.Here, we show that inhibition of mechanistic/mammalian Target of Rapamycin (mTOR) complex 1 (mTORC1) by rapamycin or the Wnt-?-catenin signalling activator TWS119 in activated human naive T cells leads to the induction of TSCM cells. We show that these compounds switch T cell metabolism to fatty acid oxidation as favoured metabolic programme for TSCM cell generation. Of note, pharmacologically induced TSCM cells possess superior functional features as a long-term repopulation capacity after adoptive transfer. Furthermore, we provide insights into the transcriptome of TSCM cells.Our data identify a mechanism of pharmacological mTORC1 inhibitors, allowing us to confer stemness to human naive T cells which may be significantly relevant for the design of innovative T cell-based cancer immunotherapies. äModulation of mTOR Signalling Triggers the Formation of Stem Cell-like(epmc).pdf DeepDyve Pubget Overpricing