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10.1128/AAC.02485-15 http://scihub22266oqcxt.onion/10.1128/AAC.02485-15 C4775987!4775987 !26711761     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=26711761 &cmd=llinks): Failed to open stream: HTTP request failed! 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Exploring Synergy between Classic Mutagens and Antibiotics To Examine Mechanisms of Synergy and Antibiotic Action |pdf=|usr=}}{{26711761 }} gab.com Text Exploring Synergy between Classic Mutagens and Antibiotics To Examine Mechanisms of Synergy and Antibiotic Action JO: Antimicrob Agents Chemother http://www.kidney.de/pget.php?&tw=1&pmid=26711761 #FOAvip We used classical mutagens in Gram-negative Escherichia coli to study synergies with different classes of antibiotics, test models of antibiotic mechanisms of action, and examine the basis of synergy. We used 4-nitroquinoline 1-oxide (4NQO), zebularine (ZEB), 5-azacytidine (5AZ), 2-aminopurine (2AP), and 5-bromodeoxyuridine (5BrdU) as mutagens (with bactericidal potency of 4NQO > ZEB > 5AZ > 2AP > 5BrdU) and vancomycin (VAN), ciprofloxacin (CPR), trimethoprim (TMP), gentamicin (GEN), tetracycline (TET), erythromycin (ERY), and chloramphenicol (CHL) as antibiotics. We detected the strongest synergies with 4NQO, an agent that oxidizes guanines and ultimately results in double-strand breaks when paired with the bactericidal antibiotics VAN, TMP, CPR, and GEN, but no synergies with the bacteriostatic antibiotics TET, ERY, and CHL. Each of the other mutagens displays synergies with the bactericidal antibiotics to various degrees that reflect their potencies, as well as with some of the other mutagens. The results support recent models showing that bactericidal antibiotics kill bacteria principally by ultimately generating more double-strand breaks than can be repaired. We discuss the synergies seen here and elsewhere as representing dose effects of not the proximal target damage but rather the ultimate resulting double-strand breaks. We also used the results of pairwise tests to place the classic mutagens into functional antibacterial categories within a previously defined drug interaction network. Twit Text FOAVip Exploring Synergy between Classic Mutagens and Antibiotics To Examine Mechanisms of Synergy and Antibiotic Action ????Antimicrob Agents Chemother http://www.kidney.de/pget.php?&tw=1&pmid=26711761 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26711761 #FOAvip English Wikipedia <ref>{{Cite pmid|26711761 }}</ref> Exploring Synergy between Classic Mutagens and Antibiotics To Examine Mechanisms of Synergy and Antibiotic Action #MMPMID26711761 Song LY ; D'Souza S ; Lam K ; Kang TM ; Yeh P ; Miller JH Antimicrob Agents Chemother 2015[Dec]; 60 (3 ): 1515-20 PMID26711761 show ga We used classical mutagens in Gram-negative Escherichia coli to study synergies with different classes of antibiotics, test models of antibiotic mechanisms of action, and examine the basis of synergy. We used 4-nitroquinoline 1-oxide (4NQO), zebularine (ZEB), 5-azacytidine (5AZ), 2-aminopurine (2AP), and 5-bromodeoxyuridine (5BrdU) as mutagens (with bactericidal potency of 4NQO > ZEB > 5AZ > 2AP > 5BrdU) and vancomycin (VAN), ciprofloxacin (CPR), trimethoprim (TMP), gentamicin (GEN), tetracycline (TET), erythromycin (ERY), and chloramphenicol (CHL) as antibiotics. We detected the strongest synergies with 4NQO, an agent that oxidizes guanines and ultimately results in double-strand breaks when paired with the bactericidal antibiotics VAN, TMP, CPR, and GEN, but no synergies with the bacteriostatic antibiotics TET, ERY, and CHL. Each of the other mutagens displays synergies with the bactericidal antibiotics to various degrees that reflect their potencies, as well as with some of the other mutagens. The results support recent models showing that bactericidal antibiotics kill bacteria principally by ultimately generating more double-strand breaks than can be repaired. We discuss the synergies seen here and elsewhere as representing dose effects of not the proximal target damage but rather the ultimate resulting double-strand breaks. We also used the results of pairwise tests to place the classic mutagens into functional antibacterial categories within a previously defined drug interaction network. |*Drug Synergism [MESH] |2-Aminopurine/pharmacology [MESH] |4-Nitroquinoline-1-oxide/pharmacology [MESH] |Anti-Bacterial Agents/*pharmacology [MESH] |Azacitidine/pharmacology [MESH] |Bromodeoxyuridine/pharmacology [MESH] |Chloramphenicol/pharmacology [MESH] |Ciprofloxacin/pharmacology [MESH] |Cytidine/analogs & derivatives/pharmacology [MESH] |DNA Breaks, Double-Stranded/*drug effects [MESH] |Erythromycin/pharmacology [MESH] |Escherichia coli/*drug effects [MESH] |Gentamicins/pharmacology [MESH] |Microbial Sensitivity Tests [MESH] |Mutagens/*pharmacology [MESH] |Tetracycline/pharmacology [MESH] |Trimethoprim/pharmacology [MESH]Exploring Synergy between Classic Mutagens and Antibiotics To Examine (epmc).pdf DeepDyve Pubget Overpricing