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10.7150/thno.14334 http://scihub22266oqcxt.onion/10.7150/thno.14334 C4775866!4775866!26941849     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Theranostics 2016 ; 6 (4): 571-93 Nephropedia Template TP {{tp|p=26941849|t=2016. Glycogen Synthase Kinase-3 (GSK-3)-Targeted Therapy and Imaging |pdf=|usr=}}{{26941849}} gab.com Text Glycogen Synthase Kinase-3 (GSK-3)-Targeted Therapy and Imaging JO: Theranostics http://www.kidney.de/pget.php?&tw=1&pmid=26941849 #FOAvip Glycogen synthase kinase-3 (GSK-3) is associated with various key biological processes, including glucose regulation, apoptosis, protein synthesis, cell signaling, cellular transport, gene transcription, proliferation, and intracellular communication. Accordingly, GSK-3 has been implicated in a wide variety of diseases and specifically targeted for both therapeutic and imaging applications by a large number of academic laboratories and pharmaceutical companies. Here, we review the structure, function, expression levels, and ligand-binding properties of GSK-3 and its connection to various diseases. A selected list of highly potent GSK-3 inhibitors, with IC50 <20 nM for adenosine triphosphate (ATP)-competitive inhibitors and IC50 <5 ?M for non-ATP-competitive inhibitors, were analyzed for structure activity relationships. Furthermore, ubiquitous expression of GSK-3 and its possible impact on therapy and imaging are also highlighted. Finally, a rational perspective and possible route to selective and effective GSK-3 inhibitors is discussed. Twit Text FOAVip Glycogen Synthase Kinase-3 (GSK-3)-Targeted Therapy and Imaging ????Theranostics http://www.kidney.de/pget.php?&tw=1&pmid=26941849 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26941849 #FOAvip English Wikipedia <ref>{{Cite pmid|26941849}}</ref> Glycogen Synthase Kinase-3 (GSK-3)-Targeted Therapy and Imaging #MMPMID26941849 Pandey MK; DeGrado TR Theranostics 2016[]; 6 (4): 571-93 PMID26941849show ga Glycogen synthase kinase-3 (GSK-3) is associated with various key biological processes, including glucose regulation, apoptosis, protein synthesis, cell signaling, cellular transport, gene transcription, proliferation, and intracellular communication. Accordingly, GSK-3 has been implicated in a wide variety of diseases and specifically targeted for both therapeutic and imaging applications by a large number of academic laboratories and pharmaceutical companies. Here, we review the structure, function, expression levels, and ligand-binding properties of GSK-3 and its connection to various diseases. A selected list of highly potent GSK-3 inhibitors, with IC50 <20 nM for adenosine triphosphate (ATP)-competitive inhibitors and IC50 <5 ?M for non-ATP-competitive inhibitors, were analyzed for structure activity relationships. Furthermore, ubiquitous expression of GSK-3 and its possible impact on therapy and imaging are also highlighted. Finally, a rational perspective and possible route to selective and effective GSK-3 inhibitors is discussed. äGlycogen Synthase Kinase-3 (GSK-3)-Targeted Therapy and Imaging (epmc).pdf DeepDyve Pubget Overpricing