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10.1002/mc.22387 http://scihub22266oqcxt.onion/10.1002/mc.22387 C4775445!4775445!26333203     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Mol+Carcinog 2016 ; 55 (10): 1449-57 Nephropedia Template TP {{tp|p=26333203|t=2016. Calcium/magnesium intake ratio, but not magnesium intake, interacts with genetic polymorphism in relation to colorectal neoplasia in a two-phase study |pdf=|usr=}}{{26333203}} gab.com Text Calcium/magnesium intake ratio, but not magnesium intake, interacts with genetic polymorphism in relation to colorectal neoplasia in a two-phase study JO: Mol Carcinog http://www.kidney.de/pget.php?&tw=1&pmid=26333203 #FOAvip Background: Some studies suggest that the calcium to magnesium ratio intakes modifies the associations of calcium or magnesium with risk of colorectal adenoma, adenoma recurrence and cancer. Parathyroid hormone (PTH) plays a key role in the regulation of homeostasis for both calcium and magnesium. We hypothesized that polymorphisms in PTH and 13 other genes may modify the association between the calcium/magnesium intake ratio and colorectal neoplasia risk. Methods: We conducted a two-phase study including 1,336 cases and 2,891 controls from the Tennessee Colorectal Polyp Study. Results: In Phase I, we identified 19 SNPs that significantly interacted with the calcium/magnesium intake ratio in adenoma risk. In Phase II, rs11022858 in PTH was replicated. In combined analysis of phases I and II, we found high calcium/magnesium intake ratio tended to be associated with a reduced risk of colorectal adenoma (p for trend, 0.040) among those who carried the TT genotype in rs11022858. In stratified analyses, calcium intake (?1000 mg/day) was significantly associated with 64% reduced adenoma risk (OR=0.36 (95% CI: 0.18?0.74)) among those homozygous for the minor allele (TT genotype) (p for trend, 0.012), but not associated with risk in other genotypes (CC/TC). Conversely, we found highest magnesium intake was significantly associated with 27% reduced risk (OR=0.73 (95% CI: 0.54?0.97)) of colorectal adenoma (p for trend, 0.026) among those who possessed the CC/TC genotypes, particularly among those with the TC genotype; whereas magnesium intake was not linked to risk among those with the TT genotype. Conclusions: These findings, if confirmed, will help for the development of personalized prevention strategies for colorectal cancer. Twit Text FOAVip Calcium/magnesium intake ratio, but not magnesium intake, interacts with genetic polymorphism in relation to colorectal neoplasia in a two-phase study ????Mol Carcinog http://www.kidney.de/pget.php?&tw=1&pmid=26333203 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26333203 #FOAvip English Wikipedia <ref>{{Cite pmid|26333203}}</ref> Calcium/magnesium intake ratio, but not magnesium intake, interacts with genetic polymorphism in relation to colorectal neoplasia in a two-phase study #MMPMID26333203 Zhu X; Shrubsole MJ; Ness RM; Hibler EA; Cai Q; Long J; Chen Z; Li G; Ming J; Hou L; Kabagambe EK; Zhang B; Smalley WE; Edwards TL; Giovannucci EL; Zheng W; Dai Q Mol Carcinog 2016[Oct]; 55 (10): 1449-57 PMID26333203show ga Background: Some studies suggest that the calcium to magnesium ratio intakes modifies the associations of calcium or magnesium with risk of colorectal adenoma, adenoma recurrence and cancer. Parathyroid hormone (PTH) plays a key role in the regulation of homeostasis for both calcium and magnesium. We hypothesized that polymorphisms in PTH and 13 other genes may modify the association between the calcium/magnesium intake ratio and colorectal neoplasia risk. Methods: We conducted a two-phase study including 1,336 cases and 2,891 controls from the Tennessee Colorectal Polyp Study. Results: In Phase I, we identified 19 SNPs that significantly interacted with the calcium/magnesium intake ratio in adenoma risk. In Phase II, rs11022858 in PTH was replicated. In combined analysis of phases I and II, we found high calcium/magnesium intake ratio tended to be associated with a reduced risk of colorectal adenoma (p for trend, 0.040) among those who carried the TT genotype in rs11022858. In stratified analyses, calcium intake (?1000 mg/day) was significantly associated with 64% reduced adenoma risk (OR=0.36 (95% CI: 0.18?0.74)) among those homozygous for the minor allele (TT genotype) (p for trend, 0.012), but not associated with risk in other genotypes (CC/TC). Conversely, we found highest magnesium intake was significantly associated with 27% reduced risk (OR=0.73 (95% CI: 0.54?0.97)) of colorectal adenoma (p for trend, 0.026) among those who possessed the CC/TC genotypes, particularly among those with the TC genotype; whereas magnesium intake was not linked to risk among those with the TT genotype. Conclusions: These findings, if confirmed, will help for the development of personalized prevention strategies for colorectal cancer. äCalcium/magnesium intake ratio, but not magnesium intake, interacts wi(epmc).pdf DeepDyve Pubget Overpricing