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10.1002/mc.22387 http://scihub22266oqcxt.onion/10.1002/mc.22387 C4775445!4775445 !26333203     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=26333203 &cmd=llinks): Failed to open stream: HTTP request failed! 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Calcium/magnesium intake ratio, but not magnesium intake, interacts with genetic polymorphism in relation to colorectal neoplasia in a two-phase study |pdf=|usr=}}{{26333203 }} gab.com Text Calcium/magnesium intake ratio, but not magnesium intake, interacts with genetic polymorphism in relation to colorectal neoplasia in a two-phase study JO: Mol Carcinog http://www.kidney.de/pget.php?&tw=1&pmid=26333203 #FOAvip Some studies suggest that the calcium to magnesium ratio intakes modify the associations of calcium or magnesium with risk of colorectal adenoma, adenoma recurrence, and cancer. Parathyroid hormone (PTH) plays a key role in the regulation of homeostasis for both calcium and magnesium. We hypothesized that polymorphisms in PTH and 13 other genes may modify the association between the calcium/magnesium intake ratio and colorectal neoplasia risk. We conducted a two-phase study including 1336 cases and 2891 controls from the Tennessee Colorectal Polyp Study. In Phase I, we identified 19 SNPs that significantly interacted with the calcium/magnesium intake ratio in adenoma risk. In Phase II, rs11022858 in PTH was replicated. In combined analysis of phases I and II, we found high calcium/magnesium intake ratio tended to be associated with a reduced risk of colorectal adenoma (P for trend, 0.040) among those who carried the TT genotype in rs11022858. In stratified analyses, calcium intake (??1000?mg/d) was significantly associated with 64% reduced adenoma risk (OR?=?0.36 (95% CI?:?0.18-0.74)) among those homozygous for the minor allele (TT genotype) (P for trend, 0.012), but not associated with risk in other genotypes (CC/TC). Conversely, we found that highest magnesium intake was significantly associated with 27% reduced risk (OR?=?0.73 (95% CI?:?0.54-0.97)) of colorectal adenoma (P for trend, 0.026) among those who possessed the CC/TC genotypes, particularly among those with the TC genotype, whereas magnesium intake was not linked to risk among those with the TT genotype. These findings, if confirmed, will help for the development of personalized prevention strategies for colorectal cancer. © 2015 Wiley Periodicals, Inc. Twit Text FOAVip Calcium/magnesium intake ratio, but not magnesium intake, interacts with genetic polymorphism in relation to colorectal neoplasia in a two-phase study ????Mol Carcinog http://www.kidney.de/pget.php?&tw=1&pmid=26333203 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26333203 #FOAvip English Wikipedia <ref>{{Cite pmid|26333203 }}</ref> Calcium/magnesium intake ratio, but not magnesium intake, interacts with genetic polymorphism in relation to colorectal neoplasia in a two-phase study #MMPMID26333203 Zhu X ; Shrubsole MJ ; Ness RM ; Hibler EA ; Cai Q ; Long J ; Chen Z ; Li G ; Jiang M ; Hou L ; Kabagambe EK ; Zhang B ; Smalley WE ; Edwards TL ; Giovannucci EL ; Zheng W ; Dai Q Mol Carcinog 2016[Oct]; 55 (10 ): 1449-57 PMID26333203 show ga Some studies suggest that the calcium to magnesium ratio intakes modify the associations of calcium or magnesium with risk of colorectal adenoma, adenoma recurrence, and cancer. Parathyroid hormone (PTH) plays a key role in the regulation of homeostasis for both calcium and magnesium. We hypothesized that polymorphisms in PTH and 13 other genes may modify the association between the calcium/magnesium intake ratio and colorectal neoplasia risk. We conducted a two-phase study including 1336 cases and 2891 controls from the Tennessee Colorectal Polyp Study. In Phase I, we identified 19 SNPs that significantly interacted with the calcium/magnesium intake ratio in adenoma risk. In Phase II, rs11022858 in PTH was replicated. In combined analysis of phases I and II, we found high calcium/magnesium intake ratio tended to be associated with a reduced risk of colorectal adenoma (P for trend, 0.040) among those who carried the TT genotype in rs11022858. In stratified analyses, calcium intake (??1000?mg/d) was significantly associated with 64% reduced adenoma risk (OR?=?0.36 (95% CI?:?0.18-0.74)) among those homozygous for the minor allele (TT genotype) (P for trend, 0.012), but not associated with risk in other genotypes (CC/TC). Conversely, we found that highest magnesium intake was significantly associated with 27% reduced risk (OR?=?0.73 (95% CI?:?0.54-0.97)) of colorectal adenoma (P for trend, 0.026) among those who possessed the CC/TC genotypes, particularly among those with the TC genotype, whereas magnesium intake was not linked to risk among those with the TT genotype. These findings, if confirmed, will help for the development of personalized prevention strategies for colorectal cancer. © 2015 Wiley Periodicals, Inc. |*Polymorphism, Single Nucleotide [MESH] |Adult [MESH] |Aged [MESH] |Calcium, Dietary/*administration & dosage [MESH] |Clinical Trials, Phase I as Topic [MESH] |Clinical Trials, Phase II as Topic [MESH] |Colorectal Neoplasms/genetics/*prevention & control [MESH] |Female [MESH] |Humans [MESH] |Magnesium/*administration & dosage [MESH] |Male [MESH] |Middle Aged [MESH] |Parathyroid Hormone/*genetics [MESH] |Protein Serine-Threonine Kinases/*genetics [MESH]Calcium/magnesium intake ratio, but not magnesium intake, interacts wi(epmc).pdf DeepDyve Pubget Overpricing