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2016 ; 12
(9
): 1222-1229
Nephropedia Template TP
gab.com Text
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Integrating Cell Phone Imaging with Magnetic Levitation (i-LEV) for Label-Free
Blood Analysis at the Point-of-Living
#MMPMID26523938
Baday M
; Calamak S
; Durmus NG
; Davis RW
; Steinmetz LM
; Demirci U
Small
2016[Mar]; 12
(9
): 1222-1229
PMID26523938
show ga
There is an emerging need for portable, robust, inexpensive, and easy-to-use
disease diagnosis and prognosis monitoring platforms to share health information
at the point-of-living, including clinical and home settings. Recent advances in
digital health technologies have improved early diagnosis, drug treatment, and
personalized medicine. Smartphones with high-resolution cameras and high data
processing power enable intriguing biomedical applications when integrated with
diagnostic devices. Further, these devices have immense potential to contribute
to public health in resource-limited settings where there is a particular need
for portable, rapid, label-free, easy-to-use, and affordable biomedical devices
to diagnose and continuously monitor patients for precision medicine, especially
those suffering from rare diseases, such as sickle cell anemia, thalassemia, and
chronic fatigue syndrome. Here, a magnetic levitation-based diagnosis system is
presented in which different cell types (i.e., white and red blood cells) are
levitated in a magnetic gradient and separated due to their unique densities.
Moreover, an easy-to-use, smartphone incorporated levitation system for cell
analysis is introduced. Using our portable imaging magnetic levitation (i-LEV)
system, it is shown that white and red blood cells can be identified and cell
numbers can be quantified without using any labels. In addition, cells levitated
in i-LEV can be distinguished at single-cell resolution, potentially enabling
diagnosis and monitoring, as well as clinical and research applications.
free
free
free
