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10.1016/j.it.2016.01.004

http://scihub22266oqcxt.onion/10.1016/j.it.2016.01.004
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C4775398!4775398!26858199
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suck abstract from ncbi


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pmid26858199      Trends+Immunol 2016 ; 37 (3): 208-20
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  • The nature of myeloid-derived suppressor cells in the tumor microenvironment #MMPMID26858199
  • Kumar V; Patel S; Tcyganov E; Gabrilovich DI
  • Trends Immunol 2016[Mar]; 37 (3): 208-20 PMID26858199show ga
  • Myeloid-derived suppressor cells (MDSC) are one of the major components of the tumor microenvironment. The main feature of these cells is their potent immune suppressive activity. MDSC are generated in the bone marrow, and in tumor-bearing hosts, migrate to peripheral lymphoid organs and the tumor to contribute to the formation of the tumor microenvironment. Recent findings have revealed differences in the function and fate of MDSC in the tumor and peripheral lymphoid organs. We review these findings here, and in this context we discuss the current understanding as to the nature of these differences, the underlying mechanisms, and their potential impact on the regulation of tumor progression.
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