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10.1126/science.1254009 http://scihub22266oqcxt.onion/10.1126/science.1254009 C4774895!4774895!25214634     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Science 2014 ; 345 (6202): 1254009 Nephropedia Template TP {{tp|p=25214634|t=2014. Innate lymphoid cells regulate intestinal epithelial cell glycosylation |pdf=|usr=}}{{25214634}} gab.com Text Innate lymphoid cells regulate intestinal epithelial cell glycosylation JO: Science http://www.kidney.de/pget.php?&tw=1&pmid=25214634 #FOAvip Fucosylation of intestinal epithelial cells, catalyzed by fucosyltransferase 2 (Fut2), is a major glycosylation mechanism of host?microbiota symbiosis. Commensal bacteria induce epithelial fucosylation, and epithelial fucose is used as a dietary carbohydrate by many of these bacteria. However, the molecular and cellular mechanisms that regulate the induction of epithelial fucosylation are unknown. Here, we show that type 3 innate lymphoid cells (ILC3) induced intestinal epithelial Fut2 expression and fucosylation in mice. This induction required the cytokines interleukin-22 and lymphotoxin in a commensal bacteria?dependent and ?independent manner, respectively. Disruption of intestinal fucosylation led to increased susceptibility to infection by Salmonella typhimurium. Our data reveal a role for ILC3 in shaping the gut microenvironment through the regulation of epithelial glycosylation. Twit Text FOAVip Innate lymphoid cells regulate intestinal epithelial cell glycosylation ????Science http://www.kidney.de/pget.php?&tw=1&pmid=25214634 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25214634 #FOAvip English Wikipedia <ref>{{Cite pmid|25214634}}</ref> Innate lymphoid cells regulate intestinal epithelial cell glycosylation #MMPMID25214634 Goto Y; Obata T; Kunisawa J; Sato S; Ivanov II; Lamichhane A; Takeyama N; Kamioka M; Sakamoto M; Matsuki T; Setoyama H; Imaoka A; Uematsu S; Akira S; Domino SE; Kulig P; Becher B; Renauld JC; Sasakawa C; Umesaki Y; Benno Y; Kiyono H Science 2014[Sep]; 345 (6202): 1254009 PMID25214634show ga Fucosylation of intestinal epithelial cells, catalyzed by fucosyltransferase 2 (Fut2), is a major glycosylation mechanism of host?microbiota symbiosis. Commensal bacteria induce epithelial fucosylation, and epithelial fucose is used as a dietary carbohydrate by many of these bacteria. However, the molecular and cellular mechanisms that regulate the induction of epithelial fucosylation are unknown. Here, we show that type 3 innate lymphoid cells (ILC3) induced intestinal epithelial Fut2 expression and fucosylation in mice. This induction required the cytokines interleukin-22 and lymphotoxin in a commensal bacteria?dependent and ?independent manner, respectively. Disruption of intestinal fucosylation led to increased susceptibility to infection by Salmonella typhimurium. Our data reveal a role for ILC3 in shaping the gut microenvironment through the regulation of epithelial glycosylation. äInnate lymphoid cells regulate intestinal epithelial cell glycosylatio(epmc).pdf DeepDyve Pubget Overpricing