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10.1002/wsbm.59 http://scihub22266oqcxt.onion/10.1002/wsbm.59 C4774529!4774529!20836031     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Wiley+Interdiscip+Rev+Syst+Biol+Med 2010 ; 2 (3): 305-23 Nephropedia Template TP {{tp|p=20836031|t=2010. Building the Developmental Oculome: Vertebrate Eye Development and Disease |pdf=|usr=}}{{20836031}} gab.com Text Building the Developmental Oculome: Vertebrate Eye Development and Disease JO: Wiley Interdiscip Rev Syst Biol Med http://www.kidney.de/pget.php?&tw=1&pmid=20836031 #FOAvip The vertebrate eye is a sophisticated multi-component organ that has been actively studied for over a century, resulting in the identification of the major embryonic and molecular events involved in its complex developmental program. Data gathered so far provides sufficient information to construct a rudimentary network of the various signaling molecules, transcription factors and their targets for several key stages of this process. With the advent of genomic technologies, there has been a rapid expansion in our ability to collect and process biological information, and the use of systems-level approaches to study specific aspects of vertebrate eye development has already commenced. This is beginning to result in the definition of the dynamic developmental networks that operate in ocular tissues, and the interactions of such networks between coordinately developing ocular tissues. Such an integrative understanding of the eye by a comprehensive systems-level analysis can be termed the ?oculome?, and that of serial developmental stages of the eye as it transits from its initiation to a fully formed functional organ represents the ?developmental oculome?. Construction of the developmental oculome will allow novel mechanistic insights that are essential for organ regeneration-based therapeutic applications, and the generation of computational models for eye disease states to predict the effects of drugs. This review discusses our present understanding of two of the individual components of the developing vertebrate eye ? the lens and retina ? at both the molecular and systems levels, and outlines the directions and tools required for construction of the developmental oculome. Twit Text FOAVip Building the Developmental Oculome: Vertebrate Eye Development and Disease ????Wiley Interdiscip Rev Syst Biol Med http://www.kidney.de/pget.php?&tw=1&pmid=20836031 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=20836031 #FOAvip English Wikipedia <ref>{{Cite pmid|20836031}}</ref> Building the Developmental Oculome: Vertebrate Eye Development and Disease #MMPMID20836031 Lachke SA; Maas RL Wiley Interdiscip Rev Syst Biol Med 2010[May]; 2 (3): 305-23 PMID20836031show ga The vertebrate eye is a sophisticated multi-component organ that has been actively studied for over a century, resulting in the identification of the major embryonic and molecular events involved in its complex developmental program. Data gathered so far provides sufficient information to construct a rudimentary network of the various signaling molecules, transcription factors and their targets for several key stages of this process. With the advent of genomic technologies, there has been a rapid expansion in our ability to collect and process biological information, and the use of systems-level approaches to study specific aspects of vertebrate eye development has already commenced. This is beginning to result in the definition of the dynamic developmental networks that operate in ocular tissues, and the interactions of such networks between coordinately developing ocular tissues. Such an integrative understanding of the eye by a comprehensive systems-level analysis can be termed the ?oculome?, and that of serial developmental stages of the eye as it transits from its initiation to a fully formed functional organ represents the ?developmental oculome?. Construction of the developmental oculome will allow novel mechanistic insights that are essential for organ regeneration-based therapeutic applications, and the generation of computational models for eye disease states to predict the effects of drugs. This review discusses our present understanding of two of the individual components of the developing vertebrate eye ? the lens and retina ? at both the molecular and systems levels, and outlines the directions and tools required for construction of the developmental oculome. äBuilding the Developmental Oculome: Vertebrate Eye Development and Dis(epmc).pdf DeepDyve Pubget Overpricing