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10.3892/ol.2016.4168 http://scihub22266oqcxt.onion/10.3892/ol.2016.4168 C4774429!4774429!26998110     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=26998110&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Oncol+Lett 2016 ; 11 (3): 1980-6 Nephropedia Template TP {{tp|p=26998110|t=2016. PKM2 and cancer: The function of PKM2 beyond glycolysis |pdf=|usr=}}{{26998110}} gab.com Text PKM2 and cancer: The function of PKM2 beyond glycolysis JO: Oncol Lett http://www.kidney.de/pget.php?&tw=1&pmid=26998110 #FOAvip Metabolic reprogramming is a hallmark of cancer cells and is used by cancer cells for growth and survival. Pyruvate kinase muscle isozyme M2 (PKM2) is a limiting glycolytic enzyme that catalyzes the final step in glycolysis, which is key in tumor metabolism and growth. The present review discusses the expression and regulation of PKM2, and reports the dominant role that PKM2 plays in glycolysis to achieve the nutrient demands of cancer cell proliferation. In addition, the present study discusses the non-metabolic function of PKM2, and its role as a coactivator and protein kinase, which contributes to tumorigenesis. Furthermore, conflicting studies concerning the role of PKM2 as a therapeutic target are reviewed. The improved understanding of PKM2 may provide a noval approach for cancer treatment. Twit Text FOAVip PKM2 and cancer: The function of PKM2 beyond glycolysis ????Oncol Lett http://www.kidney.de/pget.php?&tw=1&pmid=26998110 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26998110 #FOAvip English Wikipedia <ref>{{Cite pmid|26998110}}</ref> PKM2 and cancer: The function of PKM2 beyond glycolysis #MMPMID26998110 DONG G; MAO Q; XIA W; XU Y; WANG J; XU L; JIANG F Oncol Lett 2016[Mar]; 11 (3): 1980-6 PMID26998110show ga Metabolic reprogramming is a hallmark of cancer cells and is used by cancer cells for growth and survival. Pyruvate kinase muscle isozyme M2 (PKM2) is a limiting glycolytic enzyme that catalyzes the final step in glycolysis, which is key in tumor metabolism and growth. The present review discusses the expression and regulation of PKM2, and reports the dominant role that PKM2 plays in glycolysis to achieve the nutrient demands of cancer cell proliferation. In addition, the present study discusses the non-metabolic function of PKM2, and its role as a coactivator and protein kinase, which contributes to tumorigenesis. Furthermore, conflicting studies concerning the role of PKM2 as a therapeutic target are reviewed. The improved understanding of PKM2 may provide a noval approach for cancer treatment. äPKM2 and cancer: The function of PKM2 beyond glycolysis (epmc).pdf DeepDyve Pubget Overpricing