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2016 ; 18
(ä): 58
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IgA vasculitis in adults: the performance of the EULAR/PRINTO/PRES classification
criteria in adults
#MMPMID26935833
Ho?evar A
; Rotar Z
; Jur?i? V
; Pi?em J
; ?u?nik S
; Vizjak A
; van den Broeke R
; Tom?i? M
Arthritis Res Ther
2016[Mar]; 18
(ä): 58
PMID26935833
show ga
BACKGROUND: In 2010, EULAR/PRINTO/PRES proposed new classification criteria for
paediatric IgA vasculitis (IgAV) that have a higher diagnostic sensitivity than
the 1990 ACR criteria. These criteria have so far not been evaluated in adults,
in whom IgAV is considered as a rare disease. Our main objective was to compare
the diagnostic performance of EULAR/PRINTO/PRES and ACR classification criteria
in adult IgAV. METHODS: Adult IgAV cases fulfilling the 2012 revised
International Chapel Hill Consensus Conference Nomenclature of Vasculitides
(ICHCCNV) definition of IgAV at a secondary/tertiary rheumatology referral centre
were critically reviewed in a partially retrospective and partially prospective
manner. First, we compared the diagnostic sensitivity of ACR and
EULAR/PRINTO/PRES criteria in this group of patients. Second, the diagnostic
specificity of ACR and EULAR/PRINTO/PRES was determined by applying these
criteria to a control group of patients with other systemic vasculitides.
RESULTS: Between 1 January 2010 and 31 December 2014 350 new cases of systemic
vasculitis were identified. IgAV was diagnosed in 129, and other systemic
vasculitides in 221 (123 had large, six medium and 92 small vessel vasculitis)
cases according to ICHCCNV. The diagnostic sensitivity and specificity of the
IgAV EULAR/PRINTO/PRES criteria were 99.2 % (95 % CI 95.4-99.9 %) and 86.0 %
(95 % CI 80.7-90.3 %), and of the ACR criteria 86.8 % (95 % CI 79.7-92.1 %) and
81.0 % (95 % CI 75.2-85.9 %), respectively with an inter-criteria agreement of
77.5 % (95 % CI: 70.8-84.1 %). CONCLUSIONS: In the adult population the
EULAR/PRINTO/PRES IgAV classification criteria had a higher sensitivity and
specificity than the ACR criteria.
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