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10.1038/srep22519 http://scihub22266oqcxt.onion/10.1038/srep22519 C4773763!4773763!26931825     free     free     free Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Sci+Rep 2016 ; 6 (ä): ä Nephropedia Template TP {{tp|p=26931825|t=2016. Cells release subpopulations of exosomes with distinct molecular and biological properties |pdf=|usr=}}{{26931825}} gab.com Text Cells release subpopulations of exosomes with distinct molecular and biological properties JO: Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=26931825 #FOAvip Cells release nano-sized membrane vesicles that are involved in intercellular communication by transferring biological information between cells. It is generally accepted that cells release at least three types of extracellular vesicles (EVs): apoptotic bodies, microvesicles and exosomes. While a wide range of putative biological functions have been attributed to exosomes, they are assumed to represent a homogenous population of EVs. We hypothesized the existence of subpopulations of exosomes with defined molecular compositions and biological properties. Density gradient centrifugation of isolated exosomes revealed the presence of two distinct subpopulations, differing in biophysical properties and their proteomic and RNA repertoires. Interestingly, the subpopulations mediated differential effects on the gene expression programmes in recipient cells. In conclusion, we demonstrate that cells release distinct exosome subpopulations with unique compositions that elicit differential effects on recipient cells. Further dissection of exosome heterogeneity will advance our understanding of exosomal biology in health and disease and accelerate the development of exosome-based diagnostics and therapeutics. Twit Text FOAVip Cells release subpopulations of exosomes with distinct molecular and biological properties ????Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=26931825 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26931825 #FOAvip English Wikipedia <ref>{{Cite pmid|26931825}}</ref> Cells release subpopulations of exosomes with distinct molecular and biological properties #MMPMID26931825 Willms E; Johansson HJ; Mäger I; Lee Y; Blomberg KEM; Sadik M; Alaarg A; Smith CE; Lehtiö J; EL Andaloussi S; Wood MJ; Vader P Sci Rep 2016[]; 6 (ä): ä PMID26931825show ga Cells release nano-sized membrane vesicles that are involved in intercellular communication by transferring biological information between cells. It is generally accepted that cells release at least three types of extracellular vesicles (EVs): apoptotic bodies, microvesicles and exosomes. While a wide range of putative biological functions have been attributed to exosomes, they are assumed to represent a homogenous population of EVs. We hypothesized the existence of subpopulations of exosomes with defined molecular compositions and biological properties. Density gradient centrifugation of isolated exosomes revealed the presence of two distinct subpopulations, differing in biophysical properties and their proteomic and RNA repertoires. Interestingly, the subpopulations mediated differential effects on the gene expression programmes in recipient cells. In conclusion, we demonstrate that cells release distinct exosome subpopulations with unique compositions that elicit differential effects on recipient cells. Further dissection of exosome heterogeneity will advance our understanding of exosomal biology in health and disease and accelerate the development of exosome-based diagnostics and therapeutics. äCells release subpopulations of exosomes with distinct molecular and b(epmc).pdf DeepDyve Pubget Overpricing