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10.1038/ncomms10634 http://scihub22266oqcxt.onion/10.1038/ncomms10634 C4773495!4773495!26925549     free     free     free Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nat+Commun 2016 ; 7 (ä): ä Nephropedia Template TP {{tp|p=26925549|t=2016. Chronic stress in mice remodels lymph vasculature to promote tumour cell dissemination |pdf=|usr=}}{{26925549}} gab.com Text Chronic stress in mice remodels lymph vasculature to promote tumour cell dissemination JO: Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=26925549 #FOAvip Chronic stress induces signalling from the sympathetic nervous system (SNS) and drives cancer progression, although the pathways of tumour cell dissemination are unclear. Here we show that chronic stress restructures lymphatic networks within and around tumours to provide pathways for tumour cell escape. We show that VEGFC derived from tumour cells is required for stress to induce lymphatic remodelling and that this depends on COX2 inflammatory signalling from macrophages. Pharmacological inhibition of SNS signalling blocks the effect of chronic stress on lymphatic remodelling in vivo and reduces lymphatic metastasis in preclinical cancer models and in patients with breast cancer. These findings reveal unanticipated communication between stress-induced neural signalling and inflammation, which regulates tumour lymphatic architecture and lymphogenous tumour cell dissemination. These findings suggest that limiting the effects of SNS signalling to prevent tumour cell dissemination through lymphatic routes may provide a strategy to improve cancer outcomes. Twit Text FOAVip Chronic stress in mice remodels lymph vasculature to promote tumour cell dissemination ????Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=26925549 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26925549 #FOAvip English Wikipedia <ref>{{Cite pmid|26925549}}</ref> Chronic stress in mice remodels lymph vasculature to promote tumour cell dissemination #MMPMID26925549 Le CP; Nowell CJ; Kim-Fuchs C; Botteri E; Hiller JG; Ismail H; Pimentel MA; Chai MG; Karnezis T; Rotmensz N; Renne G; Gandini S; Pouton CW; Ferrari D; Möller A; Stacker SA; Sloan EK Nat Commun 2016[]; 7 (ä): ä PMID26925549show ga Chronic stress induces signalling from the sympathetic nervous system (SNS) and drives cancer progression, although the pathways of tumour cell dissemination are unclear. Here we show that chronic stress restructures lymphatic networks within and around tumours to provide pathways for tumour cell escape. We show that VEGFC derived from tumour cells is required for stress to induce lymphatic remodelling and that this depends on COX2 inflammatory signalling from macrophages. Pharmacological inhibition of SNS signalling blocks the effect of chronic stress on lymphatic remodelling in vivo and reduces lymphatic metastasis in preclinical cancer models and in patients with breast cancer. These findings reveal unanticipated communication between stress-induced neural signalling and inflammation, which regulates tumour lymphatic architecture and lymphogenous tumour cell dissemination. These findings suggest that limiting the effects of SNS signalling to prevent tumour cell dissemination through lymphatic routes may provide a strategy to improve cancer outcomes. äChronic stress in mice remodels lymph vasculature to promote tumour ce(epmc).pdf DeepDyve Pubget Overpricing