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10.1038/ncomms10753 http://scihub22266oqcxt.onion/10.1038/ncomms10753 C4773478!4773478!26923714     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nat+Commun 2016 ; 7 (ä): ä Nephropedia Template TP {{tp|p=26923714|t=2016. Polycomb dysregulation in gliomagenesis targets a Zfp423-dependent differentiation network |pdf=|usr=}}{{26923714}} gab.com Text Polycomb dysregulation in gliomagenesis targets a Zfp423-dependent differentiation network JO: Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=26923714 #FOAvip Malignant gliomas constitute one of the most significant areas of unmet medical need, owing to the invariable failure of surgical eradication and their marked molecular heterogeneity. Accumulating evidence has revealed a critical contribution by the Polycomb axis of epigenetic repression. However, a coherent understanding of the regulatory networks affected by Polycomb during gliomagenesis is still lacking. Here we integrate transcriptomic and epigenomic analyses to define Polycomb-dependent networks that promote gliomagenesis, validating them both in two independent mouse models and in a large cohort of human samples. We find that Polycomb dysregulation in gliomagenesis affects transcriptional networks associated with invasiveness and de-differentiation. The dissection of these networks uncovers Zfp423 as a critical Polycomb-dependent transcription factor whose silencing negatively impacts survival. The anti-gliomagenic activity of Zfp423 requires interaction with the SMAD proteins within the BMP signalling pathway, pointing to a novel synergic circuit through which Polycomb inhibits BMP signalling. Twit Text FOAVip Polycomb dysregulation in gliomagenesis targets a Zfp423-dependent differentiation network ????Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=26923714 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26923714 #FOAvip English Wikipedia <ref>{{Cite pmid|26923714}}</ref> Polycomb dysregulation in gliomagenesis targets a Zfp423-dependent differentiation network #MMPMID26923714 Signaroldi E; Laise P; Cristofanon S; Brancaccio A; Reisoli E; Atashpaz S; Terreni MR; Doglioni C; Pruneri G; Malatesta P; Testa G Nat Commun 2016[]; 7 (ä): ä PMID26923714show ga Malignant gliomas constitute one of the most significant areas of unmet medical need, owing to the invariable failure of surgical eradication and their marked molecular heterogeneity. Accumulating evidence has revealed a critical contribution by the Polycomb axis of epigenetic repression. However, a coherent understanding of the regulatory networks affected by Polycomb during gliomagenesis is still lacking. Here we integrate transcriptomic and epigenomic analyses to define Polycomb-dependent networks that promote gliomagenesis, validating them both in two independent mouse models and in a large cohort of human samples. We find that Polycomb dysregulation in gliomagenesis affects transcriptional networks associated with invasiveness and de-differentiation. The dissection of these networks uncovers Zfp423 as a critical Polycomb-dependent transcription factor whose silencing negatively impacts survival. The anti-gliomagenic activity of Zfp423 requires interaction with the SMAD proteins within the BMP signalling pathway, pointing to a novel synergic circuit through which Polycomb inhibits BMP signalling. äPolycomb dysregulation in gliomagenesis targets a Zfp423-dependent dif(epmc).pdf DeepDyve Pubget Overpricing