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10.4174/astr.2016.90.3.179

http://scihub22266oqcxt.onion/10.4174/astr.2016.90.3.179
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C4773463!4773463!26942162
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suck abstract from ncbi


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pmid26942162      Ann+Surg+Treat+Res 2016 ; 90 (3): 179-82
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  • Acute hyperammonemic encephalopathy after 5-fluorouracil based chemotherapy #MMPMID26942162
  • Yi HJ; Hong KS; Moon N; Chung SS; Lee RA; Kim KH
  • Ann Surg Treat Res 2016[Mar]; 90 (3): 179-82 PMID26942162show ga
  • 5-Fluorouracil (5-FU) based chemotherapy has been commonly used to treat metastatic or advanced colon cancer as an adjuvant chemotherapy. Although the side effects of 5-FU such as gastrointestinal problems and neutropenia and thrombocytopenia are common, not many cases of 5-FU related encephalopathy are reported. Hyperammonemic encephalopathy is a rare central nervous system toxicity following 5-FU chemotherapy manifesting as altered mental status with elevated ammonia levels with no radiologic abnormality. We report one case of 5-FU induced hyperammonemic encephalopathy occurring after Folfox4 (oxaliplatin, folinic acid and 5-fluorouracil) chemotherapy in a colon cancer patient who presented with confused mental status soon after the chemotherapy and review the 5-FU related encephalopathy.
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