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10.1038/ncomms10562 http://scihub22266oqcxt.onion/10.1038/ncomms10562 C4773449!4773449 !26923114     free     free     free Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\26923114 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Nat+Commun 2016 ; 7 (ä): 10562 Nephropedia Template TP {{tp|p=26923114 |t=2016. Increased generation of Foxp3(+) regulatory T cells by manipulating antigen presentation in the thymus |pdf=|usr=}}{{26923114 }} gab.com Text Increased generation of Foxp3(+) regulatory T cells by manipulating antigen presentation in the thymus JO: Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=26923114 #FOAvip Regulatory T-cell (Treg) selection in the thymus is essential to prevent autoimmune diseases. Although important rules for Treg selection have been established, there is controversy regarding the degree of self-reactivity displayed by T-cell receptors expressed by Treg cells. In this study we have developed a model of autoimmune skin inflammation, to determine key parameters in the generation of skin-reactive Treg cells in the thymus (tTreg). tTreg development is predominantly AIRE dependent, with an AIRE-independent component. Without the knowledge of antigen recognized by skin-reactive Treg cells, we are able to enhance skin-specific tTreg cell generation using three approaches. First, we increase medullary thymic epithelial cells by using mice lacking osteoprotegerin or by adding TRANCE (RANKL, Tnfsf11). Second, we inject intrathymically peripheral dendritic cells from skin-draining sites. Finally, we inject skin tissue lysates intrathymically. These findings have implications for enhancing the generation of organ-specific Treg cells in autoimmune diseases. Twit Text FOAVip Increased generation of Foxp3(+) regulatory T cells by manipulating antigen presentation in the thymus ????Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=26923114 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26923114 #FOAvip English Wikipedia <ref>{{Cite pmid|26923114 }}</ref> Increased generation of Foxp3(+) regulatory T cells by manipulating antigen presentation in the thymus #MMPMID26923114 Lin J ; Yang L ; Silva HM ; Trzeciak A ; Choi Y ; Schwab SR ; Dustin ML ; Lafaille JJ Nat Commun 2016[Feb]; 7 (ä): 10562 PMID26923114 show ga Regulatory T-cell (Treg) selection in the thymus is essential to prevent autoimmune diseases. Although important rules for Treg selection have been established, there is controversy regarding the degree of self-reactivity displayed by T-cell receptors expressed by Treg cells. In this study we have developed a model of autoimmune skin inflammation, to determine key parameters in the generation of skin-reactive Treg cells in the thymus (tTreg). tTreg development is predominantly AIRE dependent, with an AIRE-independent component. Without the knowledge of antigen recognized by skin-reactive Treg cells, we are able to enhance skin-specific tTreg cell generation using three approaches. First, we increase medullary thymic epithelial cells by using mice lacking osteoprotegerin or by adding TRANCE (RANKL, Tnfsf11). Second, we inject intrathymically peripheral dendritic cells from skin-draining sites. Finally, we inject skin tissue lysates intrathymically. These findings have implications for enhancing the generation of organ-specific Treg cells in autoimmune diseases. |*Disease Models, Animal [MESH] |*Mice [MESH] |AIRE Protein [MESH] |Animals [MESH] |Antigen Presentation/*immunology [MESH] |Autoimmune Diseases/*immunology [MESH] |Autoimmunity/immunology [MESH] |Chimera [MESH] |Dendritic Cells/immunology [MESH] |Dermatitis/*immunology [MESH] |Dermis/cytology/immunology [MESH] |Epidermal Cells [MESH] |Epidermis/immunology [MESH] |Flow Cytometry [MESH] |Forkhead Transcription Factors/immunology [MESH] |Mice, Knockout [MESH] |Mice, Transgenic [MESH] |Organ Culture Techniques [MESH] |Osteoprotegerin/genetics [MESH] |RANK Ligand/genetics/immunology [MESH] |Receptors, Antigen, T-Cell/genetics/*immunology [MESH] |Self Tolerance/immunology [MESH] |T-Lymphocytes, Regulatory/*immunology [MESH] |Thymus Gland/*immunology [MESH]Increased generation of Foxp3(+) regulatory T cells by manipulating an(epmc).pdf DeepDyve Pubget Overpricing