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10.1038/ncomms10875 http://scihub22266oqcxt.onion/10.1038/ncomms10875 C4773445!4773445!26915335     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nat+Commun 2016 ; 7 (ä): ä Nephropedia Template TP {{tp|p=26915335|t=2016. Local T/B cooperation in inflamed tissues is supported by T follicular helper-like cells |pdf=|usr=}}{{26915335}} gab.com Text Local T/B cooperation in inflamed tissues is supported by T follicular helper-like cells JO: Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=26915335 #FOAvip Autoimmune diseases and other inflammatory conditions are characterized by large lymphocytic tissue infiltrates in which T and B cells can be found in close contact. Here, using a murine airway inflammation model, we compare antigen-specific T and B cells in lung tissue versus lung-draining lymph node. In the lung we identify a B-cell population exhibiting a classical germinal centre phenotype without being organized into ectopic lymphoid tissue. By contrast, classical CXCR5+ Bcl-6+ T follicular helper cells are not present. Nevertheless, lung-infiltrating T cells exhibit follicular helper-like properties including the potential to provide help to naive B cells. The lung tissue is also a survival niche for memory T and B cells remaining in residual peribronchial infiltrates after resolution of inflammation. Collectively, this study shows the importance of T/B cooperation not only in lymph nodes but also in inflamed peripheral tissues for local antibody responses to infection and autoimmunity. Twit Text FOAVip Local T/B cooperation in inflamed tissues is supported by T follicular helper-like cells ????Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=26915335 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26915335 #FOAvip English Wikipedia <ref>{{Cite pmid|26915335}}</ref> Local T/B cooperation in inflamed tissues is supported by T follicular helper-like cells #MMPMID26915335 Vu Van D; Beier KC; Pietzke LJ; Al Baz MS; Feist RK; Gurka S; Hamelmann E; Kroczek RA; Hutloff A Nat Commun 2016[]; 7 (ä): ä PMID26915335show ga Autoimmune diseases and other inflammatory conditions are characterized by large lymphocytic tissue infiltrates in which T and B cells can be found in close contact. Here, using a murine airway inflammation model, we compare antigen-specific T and B cells in lung tissue versus lung-draining lymph node. In the lung we identify a B-cell population exhibiting a classical germinal centre phenotype without being organized into ectopic lymphoid tissue. By contrast, classical CXCR5+ Bcl-6+ T follicular helper cells are not present. Nevertheless, lung-infiltrating T cells exhibit follicular helper-like properties including the potential to provide help to naive B cells. The lung tissue is also a survival niche for memory T and B cells remaining in residual peribronchial infiltrates after resolution of inflammation. Collectively, this study shows the importance of T/B cooperation not only in lymph nodes but also in inflamed peripheral tissues for local antibody responses to infection and autoimmunity. äLocal T/B cooperation in inflamed tissues is supported by T follicular(epmc).pdf DeepDyve Pubget Overpricing