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10.1038/ncomms10838

http://scihub22266oqcxt.onion/10.1038/ncomms10838
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C4773435!4773435!26917323
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suck abstract from ncbi


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pmid26917323      Nat+Commun 2016 ; 7 (ä): ä
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  • Neurogenesis-mediated forgetting minimizes proactive interference #MMPMID26917323
  • Epp JR; Silva Mera R; Köhler S; Josselyn SA; Frankland PW
  • Nat Commun 2016[]; 7 (ä): ä PMID26917323show ga
  • Established memories may interfere with the encoding of new memories, particularly when existing and new memories overlap in content. By manipulating levels of hippocampal neurogenesis, here we show that neurogenesis regulates this form of proactive interference. Increasing hippocampal neurogenesis weakens existing memories and, in doing so, facilitates the encoding of new, conflicting (but not non-conflicting) information in mice. Conversely, decreasing neurogenesis stabilizes existing memories, and impedes the encoding of new, conflicting information. These results suggest that reduced proactive interference is an adaptive benefit of neurogenesis-induced forgetting.
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