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10.1371/journal.pone.0150226

http://scihub22266oqcxt.onion/10.1371/journal.pone.0150226
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C4773148!4773148!26930497
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suck abstract from ncbi


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pmid26930497      PLoS+One 2016 ; 11 (3): ä
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  • Lumican Inhibits SNAIL-Induced Melanoma Cell Migration Specifically by Blocking MMP-14 Activity #MMPMID26930497
  • Stasiak M; Boncela J; Perreau C; Karamanou K; Chatron-Colliet A; Proult I; Przygodzka P; Chakravarti S; Maquart FX; Kowalska MA; Wegrowski Y; Brézillon S
  • PLoS One 2016[]; 11 (3): ä PMID26930497show ga
  • Lumican, a small leucine rich proteoglycan, inhibits MMP-14 activity and melanoma cell migration in vitro and in vivo. Snail triggers epithelial-mesenchymal transitions endowing epithelial cells with migratory and invasive properties during tumor progression. The aim of this work was to investigate lumican effects on MMP-14 activity and migration of Snail overexpressing B16F1 (Snail-B16F1) melanoma cells and HT-29 colon adenocarcinoma cells. Lumican inhibits the Snail induced MMP-14 activity in B16F1 but not in HT-29 cells. In Snail-B16F1 cells, lumican inhibits migration, growth, and melanoma primary tumor development. A lumican-based strategy targeting Snail-induced MMP-14 activity might be useful for melanoma treatment.
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