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10.15252/embr.201541143 http://scihub22266oqcxt.onion/10.15252/embr.201541143 C4772978!4772978!26882550     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       EMBO+Rep 2016 ; 17 (3): 317-25 Nephropedia Template TP {{tp|p=26882550|t=2016. Chromosome misalignments induce spindle?positioning defects |pdf=|usr=}}{{26882550}} gab.com Text Chromosome misalignments induce spindle positioning defects JO: EMBO Rep http://www.kidney.de/pget.php?&tw=1&pmid=26882550 #FOAvip Cortical pulling forces on astral microtubules are essential to position the spindle. These forces are generated by cortical dynein, a minus?end directed motor. Previously, another dynein regulator termed Spindly was proposed to regulate dynein?dependent spindle positioning. However, the mechanism of how Spindly regulates spindle positioning has remained elusive. Here, we find that the misalignment of chromosomes caused by Spindly depletion is directly provoking spindle misorientation. Chromosome misalignments induced by CLIP?170 or CENP?E depletion or by noscapine treatment are similarly accompanied by severe spindle?positioning defects. We find that cortical LGN is actively displaced from the cortex when misaligned chromosomes are in close proximity. Preventing the KT recruitment of Plk1 by the depletion of PBIP1 rescues cortical LGN enrichment near misaligned chromosomes and re?establishes proper spindle orientation. Hence, KT?enriched Plk1 is responsible for the negative regulation of cortical LGN localization. In summary, we uncovered a compelling molecular link between chromosome alignment and spindle orientation defects, both of which are implicated in tumorigenesis. Twit Text FOAVip Chromosome misalignments induce spindle positioning defects ????EMBO Rep http://www.kidney.de/pget.php?&tw=1&pmid=26882550 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26882550 #FOAvip English Wikipedia <ref>{{Cite pmid|26882550}}</ref> Chromosome misalignments induce spindle?positioning defects #MMPMID26882550 Tame MA; Raaijmakers JA; Afanasyev P; Medema RH EMBO Rep 2016[Mar]; 17 (3): 317-25 PMID26882550show ga Cortical pulling forces on astral microtubules are essential to position the spindle. These forces are generated by cortical dynein, a minus?end directed motor. Previously, another dynein regulator termed Spindly was proposed to regulate dynein?dependent spindle positioning. However, the mechanism of how Spindly regulates spindle positioning has remained elusive. Here, we find that the misalignment of chromosomes caused by Spindly depletion is directly provoking spindle misorientation. Chromosome misalignments induced by CLIP?170 or CENP?E depletion or by noscapine treatment are similarly accompanied by severe spindle?positioning defects. We find that cortical LGN is actively displaced from the cortex when misaligned chromosomes are in close proximity. Preventing the KT recruitment of Plk1 by the depletion of PBIP1 rescues cortical LGN enrichment near misaligned chromosomes and re?establishes proper spindle orientation. Hence, KT?enriched Plk1 is responsible for the negative regulation of cortical LGN localization. In summary, we uncovered a compelling molecular link between chromosome alignment and spindle orientation defects, both of which are implicated in tumorigenesis. äChromosome misalignments induce spindle?positioning defects (epmc).pdf DeepDyve Pubget Overpricing