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10.1159/000369163 http://scihub22266oqcxt.onion/10.1159/000369163 C4772929!4772929 !27047929     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=27047929 &cmd=llinks): Failed to open stream: HTTP request failed! 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Modulation of MCP-1, TGF-?1, and ?-SMA Expressions in Granulation Tissue of Cutaneous Wounds Treated with Local Vitamin B Complex: An Experimental Study |pdf=|usr=}}{{27047929 }} gab.com Text Modulation of MCP-1, TGF- 1, and -SMA Expressions in Granulation Tissue of Cutaneous Wounds Treated with Local Vitamin B Complex: An Experimental Study JO: Dermatopathology (Basel) http://www.kidney.de/pget.php?&tw=1&pmid=27047929 #FOAvip Vitamin B complex can modulate the inflammatory response and activate wound healing. However, the action mechanisms involved in this process are still unclear. The aim of this study was to evaluate the effects of vitamin B complex on the modulation of monocyte chemotactic protein (MCP)-1, transforming growth factor (TGF)-?1, and ?-smooth muscle actin (?-SMA) in granulation tissue growth. Cutaneous ulcers on Wistar rats were topically treated with vitamin B complex. MCP-1, TGF-?1, and ?-SMA expressions were evaluated 24, 72, and 168 h after the treatment. Inflammatory cells were counted and collagen fibril staining was performed. After 24 h, more mononuclear cells (p ? 0.01) and a higher MCP-1 (p ? 0.05) and TGF-?1 (p ? 0.01) expression were observed. After 72 h, the number of fibroblasts and mononuclear cells (p ? 0.05) was elevated. After 168 h, an increased number of fibroblasts, myofibroblasts, and blood vessels (p ? 0.01) as well as a strong intensity of collagen fibril staining were seen. At that point, the cells presented a higher TGF-?1 expression (p ? 0.05), and the size of the ulcer area was decreased (p ? 0.01). We can conclude that vitamin B complex may stimulate a positive modulation of MCP-1, TGF-?1, and ?-SMA expressions in granulation tissue of cutaneous ulcers. Twit Text FOAVip Modulation of MCP-1, TGF- 1, and -SMA Expressions in Granulation Tissue of Cutaneous Wounds Treated with Local Vitamin B Complex: An Experimental Study ????Dermatopathology (Basel) http://www.kidney.de/pget.php?&tw=1&pmid=27047929 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27047929 #FOAvip English Wikipedia <ref>{{Cite pmid|27047929 }}</ref> Modulation of MCP-1, TGF-?1, and ?-SMA Expressions in Granulation Tissue of Cutaneous Wounds Treated with Local Vitamin B Complex: An Experimental Study #MMPMID27047929 Martinelli-Kläy CP ; Lunardi LO ; Martinelli CR ; Lombardi T ; Soares EG ; Martinelli C Dermatopathology (Basel) 2014[Aug]; 1 (2 ): 98-107 PMID27047929 show ga Vitamin B complex can modulate the inflammatory response and activate wound healing. However, the action mechanisms involved in this process are still unclear. The aim of this study was to evaluate the effects of vitamin B complex on the modulation of monocyte chemotactic protein (MCP)-1, transforming growth factor (TGF)-?1, and ?-smooth muscle actin (?-SMA) in granulation tissue growth. Cutaneous ulcers on Wistar rats were topically treated with vitamin B complex. MCP-1, TGF-?1, and ?-SMA expressions were evaluated 24, 72, and 168 h after the treatment. Inflammatory cells were counted and collagen fibril staining was performed. After 24 h, more mononuclear cells (p ? 0.01) and a higher MCP-1 (p ? 0.05) and TGF-?1 (p ? 0.01) expression were observed. After 72 h, the number of fibroblasts and mononuclear cells (p ? 0.05) was elevated. After 168 h, an increased number of fibroblasts, myofibroblasts, and blood vessels (p ? 0.01) as well as a strong intensity of collagen fibril staining were seen. At that point, the cells presented a higher TGF-?1 expression (p ? 0.05), and the size of the ulcer area was decreased (p ? 0.01). We can conclude that vitamin B complex may stimulate a positive modulation of MCP-1, TGF-?1, and ?-SMA expressions in granulation tissue of cutaneous ulcers. äModulation of MCP-1, TGF-?1, and ?-SMA Expressions in Granulation Tiss(epmc).pdf DeepDyve Pubget Overpricing