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Deprecated: Implicit conversion from float 284.79999999999995 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Neurobiol+Aging 2015 ; 36 (11): 2995-3007 Nephropedia Template TP
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THE ANTI-INFLAMMATORY GLYCOPROTEIN, CD200, RESTORES NEUROGENESIS AND ENHANCES AMYLOID PHAGOCYTOSIS IN A MOUSE MODEL OF ALZHEIMER?S DISEASE #MMPMID26315370
Varnum MM; Kiyota T; Ingraham KL; Ikezu S; Ikezu T
Neurobiol Aging 2015[Nov]; 36 (11): 2995-3007 PMID26315370show ga
Cluster of Differentiation-200 (CD200) is an anti-inflammatory glycoprotein expressed in neurons, T cells, and B cells, and its receptor is expressed on glia. Both Alzheimer?s disease (AD) patients and mouse models display age-related or amyloid-? peptide (A?)-induced reductions in CD200. The goal of this study was to determine if neuronal CD200 expression restores hippocampal neurogenesis and reduces A? in the APP mouse model. APP and wild-type mice were injected at 6 months of age with an adeno-associated virus expressing CD200 into the hippocampus, and sacrificed at 12 months. CD200 expression restored neural progenitor cell proliferation and differentiation in the subgranular and granular cell layers of the dentate gyrus and reduced diffuse but not thioflavin-S+ plaques in the hippocampus. In vitro studies demonstrated that CD200-stimulated microglia increased neural differentiation of neural stem cells and enhanced axon elongation and dendrite number. CD200 also enhanced A? uptake by microglia. These data indicate that CD200 is capable of enhancing microglia-mediated A? clearance and neural differentiation and has potential as a therapeutic for AD.