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10.1016/j.neurobiolaging.2015.07.027 http://scihub22266oqcxt.onion/10.1016/j.neurobiolaging.2015.07.027 C4772879!4772879 !26315370     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=26315370 &cmd=llinks): Failed to open stream: HTTP request failed! 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The anti-inflammatory glycoprotein, CD200, restores neurogenesis and enhances amyloid phagocytosis in a mouse model of Alzheimer s disease |pdf=|usr=}}{{26315370 }} gab.com Text The anti-inflammatory glycoprotein, CD200, restores neurogenesis and enhances amyloid phagocytosis in a mouse model of Alzheimer s disease JO: Neurobiol Aging http://www.kidney.de/pget.php?&tw=1&pmid=26315370 #FOAvip Cluster of Differentiation-200 (CD200) is an anti-inflammatory glycoprotein expressed in neurons, T cells, and B cells, and its receptor is expressed on glia. Both Alzheimer's disease patients and mouse models display age-related or amyloid-? peptide (A?)-induced reductions in CD200. The goal of this study was to determine if neuronal CD200 expression restores hippocampal neurogenesis and reduces A? in the amyloid precursor protein mouse model. Amyloid precursor protein and wild-type mice were injected at 6 months of age with an adeno-associated virus expressing CD200 into the hippocampus and sacrificed at 12 months. CD200 expression restored neural progenitor cell proliferation and differentiation in the subgranular and granular cell layers of the dentate gyrus and reduced diffuse but not thioflavin-S(+) plaques in the hippocampus. In vitro studies demonstrated that CD200-stimulated microglia increased neural differentiation of neural stem cells and enhanced axon elongation and dendrite number. CD200 also enhanced A? uptake by microglia. These data indicate that CD200 is capable of enhancing microglia-mediated A? clearance and neural differentiation and has potential as a therapeutic for Alzheimer's disease. Twit Text FOAVip The anti-inflammatory glycoprotein, CD200, restores neurogenesis and enhances amyloid phagocytosis in a mouse model of Alzheimer s disease ????Neurobiol Aging http://www.kidney.de/pget.php?&tw=1&pmid=26315370 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26315370 #FOAvip English Wikipedia <ref>{{Cite pmid|26315370 }}</ref> The anti-inflammatory glycoprotein, CD200, restores neurogenesis and enhances amyloid phagocytosis in a mouse model of Alzheimer s disease #MMPMID26315370 Varnum MM ; Kiyota T ; Ingraham KL ; Ikezu S ; Ikezu T Neurobiol Aging 2015[Nov]; 36 (11 ): 2995-3007 PMID26315370 show ga Cluster of Differentiation-200 (CD200) is an anti-inflammatory glycoprotein expressed in neurons, T cells, and B cells, and its receptor is expressed on glia. Both Alzheimer's disease patients and mouse models display age-related or amyloid-? peptide (A?)-induced reductions in CD200. The goal of this study was to determine if neuronal CD200 expression restores hippocampal neurogenesis and reduces A? in the amyloid precursor protein mouse model. Amyloid precursor protein and wild-type mice were injected at 6 months of age with an adeno-associated virus expressing CD200 into the hippocampus and sacrificed at 12 months. CD200 expression restored neural progenitor cell proliferation and differentiation in the subgranular and granular cell layers of the dentate gyrus and reduced diffuse but not thioflavin-S(+) plaques in the hippocampus. In vitro studies demonstrated that CD200-stimulated microglia increased neural differentiation of neural stem cells and enhanced axon elongation and dendrite number. CD200 also enhanced A? uptake by microglia. These data indicate that CD200 is capable of enhancing microglia-mediated A? clearance and neural differentiation and has potential as a therapeutic for Alzheimer's disease. |Amyloid beta-Peptides/*metabolism [MESH] |Amyloid beta-Protein Precursor/metabolism [MESH] |Animals [MESH] |Antigens, CD/pharmacology/*physiology [MESH] |Cell Differentiation/drug effects/genetics [MESH] |Cell Proliferation/drug effects/genetics [MESH] |Cells, Cultured [MESH] |Disease Models, Animal [MESH] |Hippocampus/cytology/*physiology [MESH] |Mice, Transgenic [MESH] |Microglia/cytology/metabolism [MESH] |Neural Stem Cells/cytology [MESH] |Neurogenesis/drug effects/*genetics [MESH] |Phagocytosis/*drug effects [MESH]The anti-inflammatory glycoprotein, CD200, restores neurogenesis and e(epmc).pdf DeepDyve Pubget Overpricing