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10.15252/embj.201592534 http://scihub22266oqcxt.onion/10.15252/embj.201592534 C4772849!4772849 !26796577     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=26796577 &cmd=llinks): Failed to open stream: HTTP request failed! 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Inducible chromatin priming is associated with the establishment of immunological memory in T cells |pdf=|usr=}}{{26796577 }} gab.com Text Inducible chromatin priming is associated with the establishment of immunological memory in T cells JO: EMBO J http://www.kidney.de/pget.php?&tw=1&pmid=26796577 #FOAvip Immunological memory is a defining feature of vertebrate physiology, allowing rapid responses to repeat infections. However, the molecular mechanisms required for its establishment and maintenance remain poorly understood. Here, we demonstrated that the first steps in the acquisition of T-cell memory occurred during the initial activation phase of naïve T cells by an antigenic stimulus. This event initiated extensive chromatin remodeling that reprogrammed immune response genes toward a stably maintained primed state, prior to terminal differentiation. Activation induced the transcription factors NFAT and AP-1 which created thousands of new DNase I-hypersensitive sites (DHSs), enabling ETS-1 and RUNX1 recruitment to previously inaccessible sites. Significantly, these DHSs remained stable long after activation ceased, were preserved following replication, and were maintained in memory-phenotype cells. We show that primed DHSs maintain regions of active chromatin in the vicinity of inducible genes and enhancers that regulate immune responses. We suggest that this priming mechanism may contribute to immunological memory in T cells by facilitating the induction of nearby inducible regulatory elements in previously activated T cells. Twit Text FOAVip Inducible chromatin priming is associated with the establishment of immunological memory in T cells ????EMBO J http://www.kidney.de/pget.php?&tw=1&pmid=26796577 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26796577 #FOAvip English Wikipedia <ref>{{Cite pmid|26796577 }}</ref> Inducible chromatin priming is associated with the establishment of immunological memory in T cells #MMPMID26796577 Bevington SL ; Cauchy P ; Piper J ; Bertrand E ; Lalli N ; Jarvis RC ; Gilding LN ; Ott S ; Bonifer C ; Cockerill PN EMBO J 2016[Mar]; 35 (5 ): 515-35 PMID26796577 show ga Immunological memory is a defining feature of vertebrate physiology, allowing rapid responses to repeat infections. However, the molecular mechanisms required for its establishment and maintenance remain poorly understood. Here, we demonstrated that the first steps in the acquisition of T-cell memory occurred during the initial activation phase of naïve T cells by an antigenic stimulus. This event initiated extensive chromatin remodeling that reprogrammed immune response genes toward a stably maintained primed state, prior to terminal differentiation. Activation induced the transcription factors NFAT and AP-1 which created thousands of new DNase I-hypersensitive sites (DHSs), enabling ETS-1 and RUNX1 recruitment to previously inaccessible sites. Significantly, these DHSs remained stable long after activation ceased, were preserved following replication, and were maintained in memory-phenotype cells. We show that primed DHSs maintain regions of active chromatin in the vicinity of inducible genes and enhancers that regulate immune responses. We suggest that this priming mechanism may contribute to immunological memory in T cells by facilitating the induction of nearby inducible regulatory elements in previously activated T cells. |*Immunologic Memory [MESH] |Animals [MESH] |Cells, Cultured [MESH] |Chemokine CCL1/genetics [MESH] |Chromatin/*metabolism [MESH] |Core Binding Factor Alpha 2 Subunit/genetics [MESH] |Deoxyribonuclease I/metabolism [MESH] |Gene Expression [MESH] |Granulocyte-Macrophage Colony-Stimulating Factor/genetics [MESH] |Humans [MESH] |Interleukin-3/genetics [MESH] |Jurkat Cells [MESH] |Mice, Transgenic [MESH] |NFATC Transcription Factors/genetics [MESH] |Proto-Oncogene Protein c-ets-1/genetics [MESH] |RNA, Messenger/metabolism [MESH] |Spleen/immunology [MESH] |T-Lymphocytes/immunology/*metabolism [MESH]Inducible chromatin priming is associated with the establishment of im(epmc).pdf DeepDyve Pubget Overpricing