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10.1093/ijnp/pyv088 http://scihub22266oqcxt.onion/10.1093/ijnp/pyv088 C4772821!4772821 !26232790     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=26232790 &cmd=llinks): Failed to open stream: HTTP request failed! 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Quetiapine Ameliorates Schizophrenia-Like Behaviors and Protects Myelin Integrity in Cuprizone Intoxicated Mice: The Involvement of Notch Signaling Pathway |pdf=|usr=}}{{26232790 }} gab.com Text Quetiapine Ameliorates Schizophrenia-Like Behaviors and Protects Myelin Integrity in Cuprizone Intoxicated Mice: The Involvement of Notch Signaling Pathway JO: Int J Neuropsychopharmacol http://www.kidney.de/pget.php?&tw=1&pmid=26232790 #FOAvip BACKGROUND: White matter disturbances and myelin impairment are key features of schizophrenia. The antipsychotic drug quetiapine can promote the maturation of oligodendrocytes, but the molecular mechanisms remain largely unknown. METHODS: The schizophrenia-like behaviors, degrees of demyelination, and levels of Notch signaling molecules in forebrains of adult male C57BL/6 mice were examined after fed with cuprizone (0.2% wt/wt) in the presence or absence of 10mg/kg/d quetiapine for 6 weeks. These parameters were also observed after the transcranial injection of Notch signaling inhibitor MW167 (1mM) daily during the last week of the treatment period. RESULTS: Quetiapine ameliorated the schizophrenia-like behaviors and decreased expression of myelin basic protein and inhibition of Notch signaling molecules, such as Notch1, Hes1, and Hes5, in the forebrain that induced by cuprizone. These beneficial effects of quetiapine were abolished by MW167. CONCLUSIONS: The antipsychotic and myelin protective effects of quetiapine are mediated by Notch signaling in a mouse model of cuprizone-induced demyelination associated with schizophrenia-like behaviors. The Notch pathway might therefore be a novel target for the development of antipsychotic drugs. Twit Text FOAVip Quetiapine Ameliorates Schizophrenia-Like Behaviors and Protects Myelin Integrity in Cuprizone Intoxicated Mice: The Involvement of Notch Signaling Pathway ????Int J Neuropsychopharmacol http://www.kidney.de/pget.php?&tw=1&pmid=26232790 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26232790 #FOAvip English Wikipedia <ref>{{Cite pmid|26232790 }}</ref> Quetiapine Ameliorates Schizophrenia-Like Behaviors and Protects Myelin Integrity in Cuprizone Intoxicated Mice: The Involvement of Notch Signaling Pathway #MMPMID26232790 Wang HN ; Liu GH ; Zhang RG ; Xue F ; Wu D ; Chen YC ; Peng Y ; Peng ZW ; Tan QR Int J Neuropsychopharmacol 2015[Aug]; 19 (2 ): ä PMID26232790 show ga BACKGROUND: White matter disturbances and myelin impairment are key features of schizophrenia. The antipsychotic drug quetiapine can promote the maturation of oligodendrocytes, but the molecular mechanisms remain largely unknown. METHODS: The schizophrenia-like behaviors, degrees of demyelination, and levels of Notch signaling molecules in forebrains of adult male C57BL/6 mice were examined after fed with cuprizone (0.2% wt/wt) in the presence or absence of 10mg/kg/d quetiapine for 6 weeks. These parameters were also observed after the transcranial injection of Notch signaling inhibitor MW167 (1mM) daily during the last week of the treatment period. RESULTS: Quetiapine ameliorated the schizophrenia-like behaviors and decreased expression of myelin basic protein and inhibition of Notch signaling molecules, such as Notch1, Hes1, and Hes5, in the forebrain that induced by cuprizone. These beneficial effects of quetiapine were abolished by MW167. CONCLUSIONS: The antipsychotic and myelin protective effects of quetiapine are mediated by Notch signaling in a mouse model of cuprizone-induced demyelination associated with schizophrenia-like behaviors. The Notch pathway might therefore be a novel target for the development of antipsychotic drugs. |Animals [MESH] |Cuprizone/*toxicity [MESH] |Demyelinating Diseases/*metabolism/pathology/prevention & control [MESH] |Injections, Intraventricular [MESH] |Male [MESH] |Mice [MESH] |Mice, Inbred C57BL [MESH] |Myelin Sheath/drug effects/metabolism/pathology [MESH] |Neuroprotective Agents/administration & dosage [MESH] |Peptides/pharmacology [MESH] |Quetiapine Fumarate/*administration & dosage [MESH] |Receptors, Notch/antagonists & inhibitors/*metabolism [MESH] |Schizophrenia/*drug therapy/*metabolism/pathology [MESH]Quetiapine Ameliorates Schizophrenia-Like Behaviors and Protects Myeli(epmc).pdf DeepDyve Pubget Overpricing