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10.1074/jbc.M113.473801

http://scihub22266oqcxt.onion/10.1074/jbc.M113.473801
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C4772756!4772756!23744067
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suck abstract from ncbi


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pmid23744067      J+Biol+Chem 2013 ; 288 (32): 23505-17
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  • c-Cbl, a Ubiquitin E3 Ligase That Targets Active ?-Catenin: A NOVEL LAYER OF Wnt SIGNALING REGULATION* #MMPMID23744067
  • Chitalia V; Shivanna S; Martorell J; Meyer R; Edelman E; Rahimi N
  • J Biol Chem 2013[Aug]; 288 (32): 23505-17 PMID23744067show ga
  • Background: Several E3 ligases regulate cytosolic ?-catenin during Wnt-off phase. The fate of critical form active ?-catenin in Wnt-on phase remains poorly defined.Results: Casitas B-lineage lymphoma (c-Cbl) ubiquitinates cytosolic ?-catenin and translocates to the nucleus with Wnt induction to also ubiquitinate active nuclear ?-catenin.Conclusion: c-Cbl is a unique E3 ligase targeting active nuclear ?-catenin.Significance: This study uncovers a novel layer of Wnt regulation.
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