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10.1038/srep22409 http://scihub22266oqcxt.onion/10.1038/srep22409 C4772627!4772627!26926165     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Sci+Rep 2016 ; 6 (ä): ä Nephropedia Template TP {{tp|p=26926165|t=2016. A PTH-responsive circadian clock operates in ex vivo mouse femur fracture healing site |pdf=|usr=}}{{26926165}} gab.com Text A PTH-responsive circadian clock operates in ex vivo mouse femur fracture healing site JO: Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=26926165 #FOAvip The circadian clock contains clock genes including Bmal1 and Period2, and it maintains an interval rhythm of approximately 24?hours (the circadian rhythm) in various organs including growth plate and articular cartilage. As endochondral ossification is involved not only in growth plate but also in fracture healing, we investigated the circadian clock functions in fracture sites undergoing healing. Our fracture models using external fixation involved femurs of Period2::Luciferase knock-in mice which enables the monitoring of endogenous circadian clock state via bioluminescence. Organ culture was performed by collecting femurs, and fracture sites were observed using bioluminescence imaging systems. Clear bioluminescence rhythms of 24-hour intervals were revealed in fracture healing sites. When parathyroid hormone (PTH) was administered to fractured femurs in organ culture, peak time of Period2::Luciferase activity in fracture sites and growth plates changed, indicating that PTH-responsive circadian clock functions in the mouse femur fracture healing site. While PTH is widely used in treating osteoporosis, many studies have reported that it contributes to improvement of fracture healing. Future studies of the role of this local clock in wound healing may reveal a novel function of the circadian timing mechanism in skeletal cells. Twit Text FOAVip A PTH-responsive circadian clock operates in ex vivo mouse femur fracture healing site ????Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=26926165 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26926165 #FOAvip English Wikipedia <ref>{{Cite pmid|26926165}}</ref> A PTH-responsive circadian clock operates in ex vivo mouse femur fracture healing site #MMPMID26926165 Kunimoto T; Okubo N; Minami Y; Fujiwara H; Hosokawa T; Asada M; Oda R; Kubo T; Yagita K Sci Rep 2016[]; 6 (ä): ä PMID26926165show ga The circadian clock contains clock genes including Bmal1 and Period2, and it maintains an interval rhythm of approximately 24?hours (the circadian rhythm) in various organs including growth plate and articular cartilage. As endochondral ossification is involved not only in growth plate but also in fracture healing, we investigated the circadian clock functions in fracture sites undergoing healing. Our fracture models using external fixation involved femurs of Period2::Luciferase knock-in mice which enables the monitoring of endogenous circadian clock state via bioluminescence. Organ culture was performed by collecting femurs, and fracture sites were observed using bioluminescence imaging systems. Clear bioluminescence rhythms of 24-hour intervals were revealed in fracture healing sites. When parathyroid hormone (PTH) was administered to fractured femurs in organ culture, peak time of Period2::Luciferase activity in fracture sites and growth plates changed, indicating that PTH-responsive circadian clock functions in the mouse femur fracture healing site. While PTH is widely used in treating osteoporosis, many studies have reported that it contributes to improvement of fracture healing. Future studies of the role of this local clock in wound healing may reveal a novel function of the circadian timing mechanism in skeletal cells. äA PTH-responsive circadian clock operates in ex vivo mouse femur fract(epmc).pdf DeepDyve Pubget Overpricing