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10.3390/nu8020079 http://scihub22266oqcxt.onion/10.3390/nu8020079 C4772043!4772043 !26891318     free     free     free Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\26891318 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Nutrients 2016 ; 8 (2 ): 79 Nephropedia Template TP {{tp|p=26891318 |t=2016. Suppression of Endogenous Glucose Production by Isoleucine and Valine and Impact of Diet Composition |pdf=|usr=}}{{26891318 }} gab.com Text Suppression of Endogenous Glucose Production by Isoleucine and Valine and Impact of Diet Composition JO: Nutrients http://www.kidney.de/pget.php?&tw=1&pmid=26891318 #FOAvip Leucine has been shown to acutely inhibit hepatic glucose production in rodents by a mechanism requiring its metabolism to acetyl-CoA in the mediobasal hypothalamus (MBH). In the early stages, all branched-chain amino acids (BCAA) are metabolized by a shared set of enzymes to produce a ketoacid, which is later metabolized to acetyl-CoA. Consequently, isoleucine and valine may also modulate glucose metabolism. To examine this possibility we performed intrahypothalamic infusions of isoleucine or valine in rats and assessed whole body glucose kinetics under basal conditions and during euglycemic pancreatic clamps. Furthermore, because high fat diet (HFD) consumption is known to interfere with central glucoregulation, we also asked whether the action of BCAAs was affected by HFD. We fed rats a lard-rich diet for a short interval and examined their response to central leucine. The results showed that both isoleucine and valine individually lowered blood glucose by decreasing liver glucose production. Furthermore, the action of the BCAA leucine was markedly attenuated by HFD feeding. We conclude that all three BCAAs centrally modulate glucose metabolism in the liver and that their action is disrupted by HFD-induced insulin resistance. Twit Text FOAVip Suppression of Endogenous Glucose Production by Isoleucine and Valine and Impact of Diet Composition ????Nutrients http://www.kidney.de/pget.php?&tw=1&pmid=26891318 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26891318 #FOAvip English Wikipedia <ref>{{Cite pmid|26891318 }}</ref> Suppression of Endogenous Glucose Production by Isoleucine and Valine and Impact of Diet Composition #MMPMID26891318 Arrieta-Cruz I ; Su Y ; Gutiérrez-Juárez R Nutrients 2016[Feb]; 8 (2 ): 79 PMID26891318 show ga Leucine has been shown to acutely inhibit hepatic glucose production in rodents by a mechanism requiring its metabolism to acetyl-CoA in the mediobasal hypothalamus (MBH). In the early stages, all branched-chain amino acids (BCAA) are metabolized by a shared set of enzymes to produce a ketoacid, which is later metabolized to acetyl-CoA. Consequently, isoleucine and valine may also modulate glucose metabolism. To examine this possibility we performed intrahypothalamic infusions of isoleucine or valine in rats and assessed whole body glucose kinetics under basal conditions and during euglycemic pancreatic clamps. Furthermore, because high fat diet (HFD) consumption is known to interfere with central glucoregulation, we also asked whether the action of BCAAs was affected by HFD. We fed rats a lard-rich diet for a short interval and examined their response to central leucine. The results showed that both isoleucine and valine individually lowered blood glucose by decreasing liver glucose production. Furthermore, the action of the BCAA leucine was markedly attenuated by HFD feeding. We conclude that all three BCAAs centrally modulate glucose metabolism in the liver and that their action is disrupted by HFD-induced insulin resistance. |*Diet [MESH] |Animals [MESH] |Blood Glucose/*metabolism [MESH] |Diet, High-Fat [MESH] |Dietary Fats/pharmacology [MESH] |Dietary Proteins/*chemistry/pharmacology [MESH] |Gluconeogenesis/*drug effects [MESH] |Hypothalamus/metabolism [MESH] |Insulin Resistance [MESH] |Isoleucine/*pharmacology [MESH] |Liver/*drug effects/metabolism [MESH] |Male [MESH] |Rats, Sprague-Dawley [MESH]Suppression of Endogenous Glucose Production by Isoleucine and Valine (epmc).pdf DeepDyve Pubget Overpricing